Linked Life Data

1525854

Source:http://linkedlifedata.com/resource/pubmed/id/1525854

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1992-10-20
pubmed:abstractText
A cadmium-resistant strain of Saccharomyces cerevisiae produces a cadmium metallothionein with the same characteristics as the copper metallothionein that is encoded by CUP1 in a copper-resistant strain. The structural gene for metallothionein from the cadmium-resistant strain resembles CUP1 in terms of the fragmentation patterns generated by restriction enzymes. Furthermore, the gene may be amplified as 2.0 kb repeating units in both the cadmium-resistant and the copper-resistant strains. However, transformants with a plasmid that carried the metallothionein gene from the cadmium-resistant strain were resistant to copper but not to cadmium. It appears that the same metallothionein gene, CUP1, is amplified in both cadmium- and copper-resistant yeasts. However, the mechanism for the cadmium-specific inducibility of the gene may be restricted to the cadmium-resistant strain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0172-8083
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:geneSymbol
CUP1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
The gene for cadmium metallothionein from a cadmium-resistant yeast appears to be identical to CUP1 in a copper-resistant strain.
pubmed:affiliation
Department of Biology, Faculty of Science, Ehime University, Matsuyama, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't