Linked Life Data

15257139

Source:http://linkedlifedata.com/resource/pubmed/id/15257139

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-7-16
pubmed:abstractText
Cognitive deficits could be alleviated by transplantation of neural stem cells in animals. Grafted cells may differentiate into neurons, thereby improving animal cognition. Alternatively, grafted cells may provide neurotrophic factors to modify neuronal functions and to alleviate cognitive deficits. To test which mechanism is underlying this recovery process, senescence-accelerated mice were transplanted with human neural stem cells into the hippocampus. The effect of cell transplantation was assessed in the Morris water maze. The survival and differentiation of grafted cells and the expression of NMDA receptors were examined. The data suggested that in addition to the neural differentiation of grafted neural stem cells, up-regulation of NMDA receptors after transplantation also contributed to the alleviation of cognitive deficits in this animal model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1739-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Elevation of NMDAR after transplantation of neural stem cells.
pubmed:affiliation
Peking University Stem Cell Research Center, 38 Xueyuan Road, Beijing 100083, P.R. China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't