Linked Life Data

1525674

Source:http://linkedlifedata.com/resource/pubmed/id/1525674

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-10-22
pubmed:abstractText
We investigated the effect of intravenous injection of human recombinant interleukin-1 beta (IL-1) on rectal temperature and prostaglandin E2 concentration in venous and arterial blood and in the push-pull perfusate in the third ventricle of rabbits. Changes in plasma prostaglandin E2 concentration in blood obtained from the marginal ear vein paralleled changes in body temperature during both monophasic and biphasic fevers. The plasma concentration of prostaglandin E2 in blood obtained from the jugular vein increased during the first phase of the biphasic fever. However, no increase in the prostaglandin E2 level in the carotid arterial blood was observed during the biphasic fever. The levels of prostaglandin E2 in the push-pull perfusate in the third ventricle were markedly elevated during both monophasic and biphasic fevers. Intracarotid infusion of prostaglandin E2 did not produce a fever nor result in a change in the prostaglandin E2 concentration of the push-pull perfusate in the third ventricle. The present results suggest that prostaglandin E2 from the blood circulation does not contribute to fever production in rabbits.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Does an increase in prostaglandin E2 in the blood circulation contribute to a febrile response in rabbits?
pubmed:affiliation
Department of Physiology, Yamaguchi University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't