Source:http://linkedlifedata.com/resource/pubmed/id/15254684
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2004-7-15
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| pubmed:abstractText |
Beta-catenin is well recognized to play a crucial role as a transcriptional factor during the early step of colorectal carcinogenesis. Some reports concerning the clinical implications of cytoplasmic and/or nuclear beta-catenin accumulation are available, though their results vary. On the other hand, the clinical implication of nuclear accumulation of beta-catenin in Dukes' D colorectal cancers (with distant metastasis) has not been investigated. To assess its value as a prognostic marker in this stage, we selected the cases with synchronous liver metastasis. Thirty-eight surgically resected primary and corresponding metastatic liver tumors were examined immunohistochemically and the relationships between nuclear beta-catenin accumulation and clinicopathological variables were analyzed. Of the 38 primary colorectal cancers analyzed, 11 (29%) showed nuclear accumulation of beta-catenin with cytoplasmic staining. Nuclear accumulation positivity was more frequently associated with lymph node metastasis than being negative [100% (11/11) vs. 67% (18/27), p=0.04]. There was a significant difference in median survival time between the nuclear beta-catenin positive group (1130 days) and the negative group (2102 days: p=0.037). Interestingly, all of the patients (9/9) in the former group had died when the recurrence was in the liver, while 42% (8/19) in the latter group had survived even if the recurrence was in the liver (p=0.03). In conclusion, though these results were obtained in a small series of patients, nuclear accumulation of beta-catenin may be a useful prognostic marker even in Dukes' D colorectal cancers.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1021-335X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
12
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
245-51
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15254684-Adult,
pubmed-meshheading:15254684-Aged,
pubmed-meshheading:15254684-Cell Line, Tumor,
pubmed-meshheading:15254684-Cell Nucleus,
pubmed-meshheading:15254684-Colorectal Neoplasms,
pubmed-meshheading:15254684-Cytoplasm,
pubmed-meshheading:15254684-Cytoskeletal Proteins,
pubmed-meshheading:15254684-Disease Progression,
pubmed-meshheading:15254684-Female,
pubmed-meshheading:15254684-Humans,
pubmed-meshheading:15254684-Immunohistochemistry,
pubmed-meshheading:15254684-Lymphatic Metastasis,
pubmed-meshheading:15254684-Male,
pubmed-meshheading:15254684-Middle Aged,
pubmed-meshheading:15254684-Neoplasm Metastasis,
pubmed-meshheading:15254684-Prognosis,
pubmed-meshheading:15254684-Proportional Hazards Models,
pubmed-meshheading:15254684-Recurrence,
pubmed-meshheading:15254684-Time Factors,
pubmed-meshheading:15254684-Trans-Activators,
pubmed-meshheading:15254684-Treatment Outcome,
pubmed-meshheading:15254684-beta Catenin
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Nuclear beta-catenin accumulation as a prognostic factor in Dukes' D human colorectal cancers.
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| pubmed:affiliation |
Pathology Division, National Cancer Center Research Institute East, Kashiwa, Chiba 277-8577, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|