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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-8-2
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pubmed:abstractText |
It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA. Therefore, regulation of translation initiation is likely to be intimately involved in modulating synaptic strength. Our understanding of the translation-initiation process has expanded greatly in recent years. In this review, we discuss various aspects of translation initiation, as well as signaling pathways that might be involved in coupling neurotransmitter and neurotrophin receptors to the translation machinery during various forms of synaptic plasticity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CPEB protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ELF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ELF4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Elf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/FMR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fmr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fragile X Mental Retardation Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Initiation Factors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:issn |
1072-0502
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
365-72
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15254214-Animals,
pubmed-meshheading:15254214-DNA-Binding Proteins,
pubmed-meshheading:15254214-Fragile X Mental Retardation Protein,
pubmed-meshheading:15254214-Humans,
pubmed-meshheading:15254214-Mice,
pubmed-meshheading:15254214-Nerve Tissue Proteins,
pubmed-meshheading:15254214-Neuronal Plasticity,
pubmed-meshheading:15254214-Neurons,
pubmed-meshheading:15254214-Peptide Initiation Factors,
pubmed-meshheading:15254214-Protein Biosynthesis,
pubmed-meshheading:15254214-RNA, Messenger,
pubmed-meshheading:15254214-RNA 5' Terminal Oligopyrimidine Sequence,
pubmed-meshheading:15254214-RNA-Binding Proteins,
pubmed-meshheading:15254214-Ribosomal Protein S6 Kinases,
pubmed-meshheading:15254214-Signal Transduction,
pubmed-meshheading:15254214-Synapses,
pubmed-meshheading:15254214-Synaptic Transmission,
pubmed-meshheading:15254214-Transcription Factors
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pubmed:articleTitle |
Synaptic plasticity and translation initiation.
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pubmed:affiliation |
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA. eklann@bcm.tmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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