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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
14
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|
pubmed:dateCreated |
2004-7-15
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pubmed:abstractText |
Following phase I studies of docetaxel and cisplatin in patients with non-small-cell lung cancer, the recommended doses of docetaxel were different for elderly (> or = 75 years) and non-elderly (< 75 years) patients. To elucidate the mechanism of the difference, the pharmacokinetics of docetaxel and cisplatin were investigated in two phase II studies separately conducted in elderly and non-elderly patients.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jul
|
|
pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:GotoKoichiK,
pubmed-author:HanadaKazuhikoK,
pubmed-author:KakinumaRyutaroR,
pubmed-author:KubotaKaoruK,
pubmed-author:MinamiHironobuH,
pubmed-author:NihoSeijiS,
pubmed-author:NishiwakiYutakaY,
pubmed-author:NokiharaHiroshiH,
pubmed-author:OgataHiroyasuH,
pubmed-author:OheYuichiY,
pubmed-author:OhmatsuHironobuH,
pubmed-author:SaijoNagahiroN,
pubmed-author:SekineIkuoI
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pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2901-8
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15254059-Adult,
pubmed-meshheading:15254059-Age Factors,
pubmed-meshheading:15254059-Aged,
pubmed-meshheading:15254059-Aged, 80 and over,
pubmed-meshheading:15254059-Antineoplastic Agents,
pubmed-meshheading:15254059-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15254059-Cisplatin,
pubmed-meshheading:15254059-Dose-Response Relationship, Drug,
pubmed-meshheading:15254059-Humans,
pubmed-meshheading:15254059-Lung Neoplasms,
pubmed-meshheading:15254059-Middle Aged,
pubmed-meshheading:15254059-Neutropenia,
pubmed-meshheading:15254059-Taxoids,
pubmed-meshheading:15254059-Treatment Outcome
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pubmed:year |
2004
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pubmed:articleTitle |
Comparison of pharmacokinetics and pharmacodynamics of docetaxel and Cisplatin in elderly and non-elderly patients: why is toxicity increased in elderly patients?
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pubmed:affiliation |
Division of Oncology/Hematology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa 277-8577, Japan. hminami@east.ncc.go.jp
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II
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