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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-15
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pubmed:abstractText |
Transforming growth factor-beta (TGF-beta) has been implicated in the development of renal fibrosis induced by unilateral ureteral obstruction (UUO). However, there is little information on signaling pathways mediating TGF-beta activity involved in molecular and cellular events leading to renal fibrosis induced by UUO. In this study, we sought to determine whether Smad3, a major signaling component of TGF-beta, mediated renal fibrosis induced by UUO.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
597-604
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15253712-Animals,
pubmed-meshheading:15253712-Apoptosis,
pubmed-meshheading:15253712-DNA-Binding Proteins,
pubmed-meshheading:15253712-Fibrosis,
pubmed-meshheading:15253712-Kidney,
pubmed-meshheading:15253712-Mice,
pubmed-meshheading:15253712-Mice, Inbred C57BL,
pubmed-meshheading:15253712-Mice, Mutant Strains,
pubmed-meshheading:15253712-Nephritis,
pubmed-meshheading:15253712-Phenotype,
pubmed-meshheading:15253712-Phosphorylation,
pubmed-meshheading:15253712-Smad2 Protein,
pubmed-meshheading:15253712-Smad3 Protein,
pubmed-meshheading:15253712-Trans-Activators,
pubmed-meshheading:15253712-Ureteral Obstruction
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pubmed:year |
2004
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pubmed:articleTitle |
Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction.
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pubmed:affiliation |
Atopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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