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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-7-14
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pubmed:abstractText |
Regular moderate alcohol (EtOH) intake seems to protect against both coronary artery disease and ischemic stroke, whereas the risk increases with heavy EtOH consumption. Effects of EtOH on endothelial cell function may be relevant to these disparate effects. Potassium channels play an important role in the regulation of endothelial cell functions. Therefore, we investigated whether Ca-activated K channels (BKCa) are modulated by EtOH. Furthermore, we examined whether EtOH-induced changes of endothelial nitric oxide (NO) formation and cell proliferation are due to BKCa activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0145-6008
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pubmed:author |
pubmed-author:BackenköhlerUlrichU,
pubmed-author:ErdoganAliA,
pubmed-author:KuhlmannChristoph R WCR,
pubmed-author:LüddersDörte WDW,
pubmed-author:LiFangF,
pubmed-author:MostAstrid KAK,
pubmed-author:NeumannThomasT,
pubmed-author:SchaeferChristian ACA,
pubmed-author:TillmannsHaraldH,
pubmed-author:WaldeckerBerndB,
pubmed-author:WiechaJohannesJ
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1005-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15252286-Cell Proliferation,
pubmed-meshheading:15252286-Cells, Cultured,
pubmed-meshheading:15252286-Dose-Response Relationship, Drug,
pubmed-meshheading:15252286-Endothelium, Vascular,
pubmed-meshheading:15252286-Ethanol,
pubmed-meshheading:15252286-Humans,
pubmed-meshheading:15252286-Nitric Oxide,
pubmed-meshheading:15252286-Potassium Channels, Calcium-Activated
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pubmed:year |
2004
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pubmed:articleTitle |
Dose-dependent activation of Ca2+-activated K+ channels by ethanol contributes to improved endothelial cell functions.
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pubmed:affiliation |
Department of Cardiology and Angiology, Justus Liebig University of Giessen, Giessen, Germany. chr_kuhlmann@web.de
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pubmed:publicationType |
Journal Article,
Comparative Study
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