Linked Life Data

15251124

Source:http://linkedlifedata.com/resource/pubmed/id/15251124

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-7-14
pubmed:abstractText
Apoptosis--the cell's intrinsic program for death--plays a central role in regulation of tissue homeostasis. Accordingly, tipping the balance between cell death and proliferation in favor of cell survival can result in tumor formation. Also, killing of cancer cells by cytotoxic therapies (e.g. chemotherapy, gamma-irradiation, immunotherapy or suicide gene therapy) largely depends on intact apoptosis programs in cancer cells. To this end, it is implied that death receptor signaling contributes to the efficacy of cancer therapy. Failure to undergo apoptosis in response to anticancer therapy can therefore result in resistance. Thus, insights into the mechanisms regulating apoptosis in response to anticancer therapy and the ways in which cancer cells evade apoptosis might provide new opportunities for drug development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1471-4892
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Signaling through death receptors in cancer therapy.
pubmed:affiliation
University Children's Hospital, Prittwitzstr 43, 89075 Ulm, Germany. simone.fulda@medizin.uni-ulm.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't