Linked Life Data

15250586

Source:http://linkedlifedata.com/resource/pubmed/id/15250586

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-7-14
pubmed:abstractText
Transient application of group I metabotropic glutamate receptor (mGluR) agonists to hippocampal slices produces ictal-like discharges that persist for hours after the removal of the agonist. This effect of group I mGluR stimulation--converting a 'normal' hippocampal slice into an 'epileptic-like' one--may represent a form of epileptogenesis. Because this epileptogenic process can be induced in vitro and it occurs within hours, it has been possible to examine the cellular and transduction processes underlying the generation and long-term maintenance of ictal-like bursts. ImGluR(V), a voltage-dependent depolarizing current activated by group I mGluR agonists, appears to play an important role in the expression of the ictal-like bursts. Long-term activation of ImGluR(V) following mGluR stimulation is a possible plastic change that enables the long-term maintenance of ictal discharges. Induction of ImGluR(V) may represent a cellular event underlying the mGluR-induced epileptogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
548
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-75
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Plasticity mechanisms underlying mGluR-induced epileptogenesis.
pubmed:affiliation
Department of Physiology, State University of New York Health Science Center at Brooklyn, USA.
pubmed:publicationType
Journal Article, Review