Source:http://linkedlifedata.com/resource/pubmed/id/15247981
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-7-12
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| pubmed:abstractText |
Oxygenation of tumor tissue has recently been assed an important prerequisite for the effectiveness of radiotherapy in cervical cancer. Hyperviscosity is a common phenomenon in malignancy and a cause of reduced oxygen transport capacity that would favour tissue hypoxia. Hemorheological variables were serially tested preoperatively, during four cycles of fractionated adjuvant IR(192) HDR after loading radiation (HDR-AL) of the vaginal vault (weekly intervals), and 6 months postoperatively in patients with cervical (n=12) and endometrial cancer (n=26). Women who were scheduled for benign tumor surgery served as controls (n=29). Preoperatively, in cervical and endometrial cancer patients, mean plasma viscosity (PV: 1.31+/-0.1 mPa s; p<0.05; 1.35+/-0.13 mPa s; p<0.001) and fibrinogen levels (383+/-46 mg/dL; p<0.05; 379+/-117 mg/dL; p<0.05) were higher as compared to the controls (1.25+/-0.07 mPa s; 314+/-89 mg/dL). Red blood cell aggregation at low shear and stasis (RBC agg.: 15.7+/-5.6; p<0.05; 29.6+/-9.1; p<0.05) was higher in endometrial cancer patients as compared to the controls (13.7+/-3.4; 25.3+/-5.6). Postoperatively PV decreased in endometrial cancer patients and transiently increased in cervical cancer patients. After the third session of irradiation in both cancer groups, PV regained and at the 6-month checkup, levels were higher as compared to the values before surgery. Postoperatively fibrinogen levels increased and remained higher throughout HDR-AL and 6 months postoperatively. After surgery and during irradiation, anemia persisted in both cancer groups while hematocrit recovered after 6 months in endometrial cancer patients. Thrombosis was diagnosed in three patients postoperatively (7.9 %) but in none during HDR-AL. While a temporary reduction of hyperviscosity is found postoperatively and during HDR-AL in uterine cancer patients, 6 months after surgery RBC aggregation, PV, and hematocrit returned to the pretreatment range.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1076-0296
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
10
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
239-48
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| pubmed:dateRevised |
2005-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15247981-Aged,
pubmed-meshheading:15247981-Biological Markers,
pubmed-meshheading:15247981-Blood Viscosity,
pubmed-meshheading:15247981-Brachytherapy,
pubmed-meshheading:15247981-Cell Hypoxia,
pubmed-meshheading:15247981-Combined Modality Therapy,
pubmed-meshheading:15247981-Endometrial Neoplasms,
pubmed-meshheading:15247981-Erythrocyte Aggregation,
pubmed-meshheading:15247981-Female,
pubmed-meshheading:15247981-Fibrinogen,
pubmed-meshheading:15247981-Humans,
pubmed-meshheading:15247981-Hysterectomy,
pubmed-meshheading:15247981-Leukocyte Count,
pubmed-meshheading:15247981-Middle Aged,
pubmed-meshheading:15247981-Platelet Count,
pubmed-meshheading:15247981-Radiotherapy, Adjuvant,
pubmed-meshheading:15247981-Uterine Cervical Neoplasms
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| pubmed:year |
2004
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| pubmed:articleTitle |
Monitoring of rheologic variables during postoperative high-dose brachytherapy for uterine cancer.
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| pubmed:affiliation |
Department of Obstetrics and Gynecology, City Hospital of Ruesselsheim, Ruesselsheim, Germany. G-F.von.Tempelhoff@gmx.de
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| pubmed:publicationType |
Journal Article
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