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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-12
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pubmed:abstractText |
Antagonists of alpha 1-adrenergic receptors (alpha 1ARs) relieve obstructive and irritative symptoms in patients with bladder outlet obstruction. However, to our knowledge mechanisms underlying the relief of irritative symptoms remain unknown. Because bladder alpha 1dARs are up-regulated in some rats with bladder outlet obstruction, we investigated the effect of the alpha 1aAR antagonist 5-methyl urapidil (5MU) vs the alpha 1a/alpha 1dAR antagonist tamsulosin on urinary frequency in obstructed rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
758-62
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15247777-Adrenergic alpha-1 Receptor Antagonists,
pubmed-meshheading:15247777-Adrenergic alpha-Agonists,
pubmed-meshheading:15247777-Adrenergic alpha-Antagonists,
pubmed-meshheading:15247777-Animals,
pubmed-meshheading:15247777-Dose-Response Relationship, Drug,
pubmed-meshheading:15247777-Hemodynamics,
pubmed-meshheading:15247777-Phenylephrine,
pubmed-meshheading:15247777-Piperazines,
pubmed-meshheading:15247777-Rats,
pubmed-meshheading:15247777-Rats, Sprague-Dawley,
pubmed-meshheading:15247777-Regression Analysis,
pubmed-meshheading:15247777-Sulfonamides,
pubmed-meshheading:15247777-Urinary Bladder Neck Obstruction,
pubmed-meshheading:15247777-Urination
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pubmed:year |
2004
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pubmed:articleTitle |
Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction.
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pubmed:affiliation |
Department of Surgery, Duke University Medical Center, and Veterans Affairs Medical Center, Durham, North Carolina 27710, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
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