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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-7-12
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pubmed:abstractText |
In humans, cytochrome P450 2A6 (CYP2A6) constitutes the principal nicotine C-oxidase. Several different polymorphic CYP2A6 gene variants are known which contribute to the highly variable expression of this enzyme among individuals. In this study we report a novel polymorphism located in the 5' flanking region (-745A > G) of the CYP2A6 gene disrupting a CCAAT box.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-314X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
369-79
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15247629-5' Flanking Region,
pubmed-meshheading:15247629-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:15247629-CCAAT-Binding Factor,
pubmed-meshheading:15247629-Carcinoma, Hepatocellular,
pubmed-meshheading:15247629-Chromatin Immunoprecipitation,
pubmed-meshheading:15247629-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:15247629-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:15247629-Gene Frequency,
pubmed-meshheading:15247629-Haplotypes,
pubmed-meshheading:15247629-Humans,
pubmed-meshheading:15247629-Liver Neoplasms,
pubmed-meshheading:15247629-Luciferases,
pubmed-meshheading:15247629-Mixed Function Oxygenases,
pubmed-meshheading:15247629-Polymorphism, Genetic,
pubmed-meshheading:15247629-Promoter Regions, Genetic,
pubmed-meshheading:15247629-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:15247629-Tumor Cells, Cultured
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pubmed:year |
2004
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pubmed:articleTitle |
Polymorphic NF-Y dependent regulation of human nicotine C-oxidase (CYP2A6).
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pubmed:affiliation |
Institute of Environmental Medicine, Division of Molecular Toxicology, Karolinska Institutet, 17177 Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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