Linked Life Data

15247511

Source:http://linkedlifedata.com/resource/pubmed/id/15247511

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-7-12
pubmed:abstractText
Osteoimmunology is the emerging concept that certain molecules link the skeletal and immune systems. The transcription factor c-Fos, a component of activator protein-1 (AP-1), is essential for osteoclast differentiation. Mice lacking c-Fos are osteopetrotic owing to impaired osteoclast development. Recent studies suggest that in contrast to this positive role in osteoclastogenesis, c-Fos expression inhibits differentiation and activation of mononuclear phagocytes. Here, we focus on the contrasting roles of c-Fos in the bone and immune lineages. Both osteoclasts and mononuclear phagocytes are derived from common myeloid precursors. Osteoclasts resorb bone, whereas macrophages and myeloid dendritic cells phagocytose microbial pathogens, initiating innate and adaptive immunity. Differentiation of the common precursors into either bone or immune lineage is determined by ligand binding to cell-surface receptors, particularly receptor activator of NF-kappa B (RANK) for osteoclasts, or Toll-like receptors (TLRs) for mononuclear phagocytes. Both RANK and TLRs activate the dimeric transcription factors NF-kappa B and AP-1. Yet, c-Fos/AP-1 plays a positive role in osteoclasts but a negative role in macrophages and dendritic cells. Further study is necessary to clarify this dual role of c-Fos.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-9717
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-84
pubmed:dateRevised
2008-8-7
pubmed:meshHeading
pubmed-meshheading:15247511-Animals, pubmed-meshheading:15247511-Cell Nucleus, pubmed-meshheading:15247511-Dendritic Cells, pubmed-meshheading:15247511-Glycoproteins, pubmed-meshheading:15247511-Leukocytes, Mononuclear, pubmed-meshheading:15247511-Macrophages, pubmed-meshheading:15247511-Mice, pubmed-meshheading:15247511-Models, Biological, pubmed-meshheading:15247511-Osteoclasts, pubmed-meshheading:15247511-Osteoprotegerin, pubmed-meshheading:15247511-Phagocytosis, pubmed-meshheading:15247511-Phosphorylation, pubmed-meshheading:15247511-Proto-Oncogene Proteins c-fos, pubmed-meshheading:15247511-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:15247511-Receptors, Tumor Necrosis Factor, pubmed-meshheading:15247511-Signal Transduction, pubmed-meshheading:15247511-Transcription Factor AP-1
pubmed:year
2004
pubmed:articleTitle
Osteoclasts, mononuclear phagocytes, and c-Fos: new insight into osteoimmunology.
pubmed:affiliation
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan. matsuo@sc.itc.keio.ac.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't