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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5683
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pubmed:dateCreated |
2004-7-26
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pubmed:abstractText |
We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression of viremia, preserving CD4 levels and permitting the induction of virus-specific cellular immunity. L-870812 was also active in chronic infection; however, the magnitude and durability of the effect varied in conjunction with the pretreatment immune response and viral load. These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:AnthonyNeville JNJ,
pubmed-author:CasimiroDanilo RDR,
pubmed-author:DanovichRobert MRM,
pubmed-author:DornadulaGeethanjaliG,
pubmed-author:EminiEmilio AEA,
pubmed-author:GabryelskiLori SLS,
pubmed-author:GomezRobert PRP,
pubmed-author:GuareJames PJP,
pubmed-author:HandtLarryL,
pubmed-author:HazudaDaria JDJ,
pubmed-author:JinLixiaL,
pubmed-author:KleinHilton JHJ,
pubmed-author:MillerMichael DMD,
pubmed-author:MotzelSherri LSL,
pubmed-author:SchleifWilliam AWA,
pubmed-author:ShiverJohn WJW,
pubmed-author:TusseyLyndaL,
pubmed-author:VaccaJoseph PJP,
pubmed-author:WaiJohn SJS,
pubmed-author:WilsonKeith A AKA,
pubmed-author:WitmerMarc VMV,
pubmed-author:YoungSteven DSD
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
305
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
528-32
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:15247437-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:15247437-Animals,
pubmed-meshheading:15247437-Anti-HIV Agents,
pubmed-meshheading:15247437-CD4 Lymphocyte Count,
pubmed-meshheading:15247437-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15247437-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15247437-Cells, Cultured,
pubmed-meshheading:15247437-Drug Resistance, Viral,
pubmed-meshheading:15247437-HIV Integrase,
pubmed-meshheading:15247437-HIV Integrase Inhibitors,
pubmed-meshheading:15247437-HIV-1,
pubmed-meshheading:15247437-Immunity, Cellular,
pubmed-meshheading:15247437-Integrase Inhibitors,
pubmed-meshheading:15247437-Integrases,
pubmed-meshheading:15247437-Leukocytes, Mononuclear,
pubmed-meshheading:15247437-Macaca mulatta,
pubmed-meshheading:15247437-Mutation,
pubmed-meshheading:15247437-Naphthyridines,
pubmed-meshheading:15247437-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:15247437-Simian immunodeficiency virus,
pubmed-meshheading:15247437-Viral Load,
pubmed-meshheading:15247437-Viremia,
pubmed-meshheading:15247437-Virus Replication
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pubmed:year |
2004
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pubmed:articleTitle |
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.
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pubmed:affiliation |
Department of Biological Chemistry, Merck Research Laboratories, Post Office Box 4, West Point, PA 19486, USA. daria_hazuda@merck.com
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pubmed:publicationType |
Journal Article
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