Linked Life Data

15247126

Source:http://linkedlifedata.com/resource/pubmed/id/15247126

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2004-7-12
pubmed:abstractText
Circulating hormones are associated with mammographic density, an intermediate marker of breast cancer risk. Differences in circulating hormones, including estrone and testosterone, have been observed in premenopausal women based on their capacity to metabolize daidzein, an isoflavone found predominantly in soybeans. Equol and O-desmethylangolensin (O-DMA) are products of intestinal bacterial metabolism of daidzein. There is interindividual variability in the capacity to produce daidzein metabolites; individuals can be equol producers or non-producers and O-DMA producers or non-producers. We tested the hypothesis that daidzein-metabolizing phenotypes are associated with mammographic density. Participants were recruited from among 92 sedentary, postmenopausal women, ages 50 to 75 years, who participated in a 1-year physical activity intervention. Pre-intervention mammographic density was determined using a computer-assisted, gray-scale thresholding technique. Fifty-five of these women consumed supplemental soy protein (>10 mg daidzein/d) for 3 days and collected a first-void urine sample on the fourth day to determine daidzein-metabolizing phenotypes. Equol and O-DMA concentrations were measured using gas chromatography-mass spectrometry. Associations between daidzein-metabolizing phenotypes and percent mammographic density were adjusted for age, maximum adult weight, gravidity, family history of breast cancer, and serum follicle-stimulating hormone and free testosterone concentrations. Mammographic density was 39% lower in equol producers compared with non-producers (P = 0.04). O-DMA producers had mammographic density 69% greater than non-producers (P = 0.05). These results suggest that particular intestinal bacterial profiles are associated with postmenopausal mammographic density, and these associations are not entirely explained by differences in reproductive or anthropometric characteristics or circulating hormones.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1156-62
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15247126-Aged, pubmed-meshheading:15247126-Breast, pubmed-meshheading:15247126-Breast Neoplasms, pubmed-meshheading:15247126-Cross-Sectional Studies, pubmed-meshheading:15247126-Dietary Supplements, pubmed-meshheading:15247126-Equol, pubmed-meshheading:15247126-Female, pubmed-meshheading:15247126-Gas Chromatography-Mass Spectrometry, pubmed-meshheading:15247126-Humans, pubmed-meshheading:15247126-Intestines, pubmed-meshheading:15247126-Isoflavones, pubmed-meshheading:15247126-Mammography, pubmed-meshheading:15247126-Middle Aged, pubmed-meshheading:15247126-Obesity, pubmed-meshheading:15247126-Phenotype, pubmed-meshheading:15247126-Phytoestrogens, pubmed-meshheading:15247126-Postmenopause, pubmed-meshheading:15247126-Soybean Proteins, pubmed-meshheading:15247126-Tumor Markers, Biological
pubmed:year
2004
pubmed:articleTitle
Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women.
pubmed:affiliation
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, USA. jlampe@fhcrc.org
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't