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pubmed:abstractText |
Ventricular fibrosis is promoted by many effectors that chronically activate phospholipase D (PLD), and induces cardiac dysfunction and heart failure in cardiovascular diseases. Since ethanolamine is a product of PLD, we hypothesised that an administration of an analogue of ethanolamine, N-methylethanolamine (MEA), decreases PLD activity through a negative feedback mechanism, suppresses collagen accumulation, and thus prevents organ dysfunction.
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pubmed:affiliation |
Department of Internal Medicine and Therapeutics,Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan. kazuhiro@medone.med.osaka-u.ac.jp
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