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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-7-12
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pubmed:abstractText |
Stress has been associated with the onset of schizophrenia and exacerbation of psychotic symptoms. Patients with schizotypal personality disorder (SPD), the prototypic schizophrenia spectrum disorder, do not develop the frank psychosis of schizophrenia and appear clinically to be less reactive to stress than schizophrenic patients. Schizophrenic patients demonstrate increased dopaminergic (DA) and hypothalamic-pituitary-adrenal-axis (HPA) activation following 2-deoxyglucose (2-DG), an acute metabolic (glycopyruvic) stressor, compared to healthy volunteers (HV). We hypothesized that SPD patients would demonstrate comparable or lower DA and HPA responses after 2-DG to HV.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0920-9964
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-31
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pubmed:dateRevised |
2010-9-2
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pubmed:meshHeading |
pubmed-meshheading:15246460-Acute Disease,
pubmed-meshheading:15246460-Adult,
pubmed-meshheading:15246460-Antimetabolites,
pubmed-meshheading:15246460-Deoxyglucose,
pubmed-meshheading:15246460-Dopamine,
pubmed-meshheading:15246460-Double-Blind Method,
pubmed-meshheading:15246460-Drug Administration Schedule,
pubmed-meshheading:15246460-Female,
pubmed-meshheading:15246460-Glucose,
pubmed-meshheading:15246460-Homovanillic Acid,
pubmed-meshheading:15246460-Humans,
pubmed-meshheading:15246460-Hydrocortisone,
pubmed-meshheading:15246460-Hypothalamo-Hypophyseal System,
pubmed-meshheading:15246460-Infusions, Intravenous,
pubmed-meshheading:15246460-Male,
pubmed-meshheading:15246460-Pituitary-Adrenal System,
pubmed-meshheading:15246460-Pyruvic Acid,
pubmed-meshheading:15246460-Schizotypal Personality Disorder
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pubmed:year |
2004
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pubmed:articleTitle |
Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizotypal personality disorder.
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pubmed:affiliation |
Department of Psychiatry, Mt. Sinai School of Medicine Clinical Reseach Center, New York, NY 10029, USA. vivian.mitropoulou@mssm.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial
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