Linked Life Data

15245790

Source:http://linkedlifedata.com/resource/pubmed/id/15245790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-7-12
pubmed:abstractText
Previous observations suggest a contribution of two APOE promoter polymorphisms (-219 G/T and -491 A/T) in dementia. From two independent populations of elderly (mean age of 84 and 85 years old, respectively), we observed that subjects bearing the -219T allele were at increased risk of dementia (OR = 1.9 (95% CI, 1.3-2.8), P = 0.0003) or AD (OR = 2.0 (95% CI, 1.2-3.4), P < 0.008). Conversely, the -491 A/T variant was not associated with this risk of dementia in the elderly, as previously described. Haplotype estimations including the two promoter and the coding APOE polymorphisms indicated that the -491A/-219T/4 haplotype was at risk for the development of dementia (OR = 3.5 (95% CI, 2.5-5.0), P < 0.0001), whereas the -491A/-219G/4 haplotype was not (OR = 1.1 (95% CI, 0.6-2.1)). Similar results were observed when restricted to Alzheimer's disease. In conclusion, these data indicate that the -219 G/T polymorphism is a genetic determinant of dementia in the elderly, independently of the 4 allele.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
365
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
116-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
APOE promoter polymorphisms and dementia in the elderly.
pubmed:affiliation
INSERM U508, Institut Pasteur de Lille, 1 rue du professeur Calmette, BP 245, 59019 Lille Cedex, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't