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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-7-12
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pubmed:abstractText |
Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruiting the IKK (I kappa B kinase) complex, a central regulator of NF-kappa B pathways, to the surface of the transforming schizont, where it becomes permanently activated. Constitutive activation of the PI-3K-PKB [phosphoinositide 3-kinase-(Akt) protein kinase B] pathway is likely to be indirect and is essential for continuous proliferation. Theileria-transformed T cells express a range of anti-apoptotic proteins that can be expected to provide protection against apoptosis induced by death receptors, as well as cellular control mechanisms that are mobilised to eliminate cells that entered a cycle of uncontrolled proliferation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CHUK protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chuk protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/IKBKB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IKBKE protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ikbkb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ikbke protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0952-7915
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
524-30
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15245750-Animals,
pubmed-meshheading:15245750-Apoptosis,
pubmed-meshheading:15245750-Humans,
pubmed-meshheading:15245750-I-kappa B Kinase,
pubmed-meshheading:15245750-MAP Kinase Signaling System,
pubmed-meshheading:15245750-Mice,
pubmed-meshheading:15245750-NF-kappa B,
pubmed-meshheading:15245750-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:15245750-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15245750-Proto-Oncogene Proteins,
pubmed-meshheading:15245750-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:15245750-Theileria,
pubmed-meshheading:15245750-Theileriasis
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pubmed:year |
2004
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pubmed:articleTitle |
The strategies of the Theileria parasite: a new twist in host-pathogen interactions.
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pubmed:affiliation |
Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, Länggassstrasse 122, CH-3012 Bern, Switzerland. dirk.dobbelaere@itpa.unibe.ch
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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