| pubmed-article:15245581 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15245581 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:15245581 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:15245581 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:15245581 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:15245581 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:15245581 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:15245581 | lifeskim:mentions | umls-concept:C2003905 | lld:lifeskim |
| pubmed-article:15245581 | pubmed:dateCreated | 2004-7-16 | lld:pubmed |
| pubmed-article:15245581 | pubmed:abstractText | A novel member of the Wnt signalling pathway, Chibby, was recently identified. This protein inhibits Wnt/beta-catenin mediated transcriptional activation by competing with Lef-1 (the transcription factor and target of beta-catenin) to bind to beta-catenin. This suggests that Chibby could be a tumour suppressor protein. The C22orf2 gene coding Chibby is located on chromosome 22, a region recurrently lost in colorectal cancer. Activation of the Wnt pathway is a major feature of colorectal cancer and occurs through inactivation of APC or activation of beta-catenin. All of this led us to analyse the possible implication of Chibby in colorectal carcinogenesis. | lld:pubmed |
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| pubmed-article:15245581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15245581 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15245581 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15245581 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15245581 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15245581 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15245581 | pubmed:issn | 1471-2407 | lld:pubmed |
| pubmed-article:15245581 | pubmed:author | pubmed-author:Laurent-PuigP... | lld:pubmed |
| pubmed-article:15245581 | pubmed:author | pubmed-author:BeaunePhilipp... | lld:pubmed |
| pubmed-article:15245581 | pubmed:author | pubmed-author:GadSophieS | lld:pubmed |
| pubmed-article:15245581 | pubmed:author | pubmed-author:BergerAnneA | lld:pubmed |
| pubmed-article:15245581 | pubmed:author | pubmed-author:LièvreAstridA | lld:pubmed |
| pubmed-article:15245581 | pubmed:author | pubmed-author:TeboulDavidD | lld:pubmed |
| pubmed-article:15245581 | pubmed:author | pubmed-author:GoasguenNicol... | lld:pubmed |
| pubmed-article:15245581 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15245581 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:15245581 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:15245581 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15245581 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15245581 | pubmed:pagination | 31 | lld:pubmed |
| pubmed-article:15245581 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15245581 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15245581 | pubmed:articleTitle | Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ? | lld:pubmed |
| pubmed-article:15245581 | pubmed:affiliation | UMR-S Inserm 490, Laboratoire de Toxicologie Moléculaire, Université René Descartes-Paris V, 75006 Paris, France. Sophie.Gad@biomedicale.univ-paris5.fr | lld:pubmed |
| pubmed-article:15245581 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15245581 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:25776 | entrezgene:pubmed | pubmed-article:15245581 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15245581 | lld:entrezgene |
