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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2004-7-16
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pubmed:abstractText |
A novel member of the Wnt signalling pathway, Chibby, was recently identified. This protein inhibits Wnt/beta-catenin mediated transcriptional activation by competing with Lef-1 (the transcription factor and target of beta-catenin) to bind to beta-catenin. This suggests that Chibby could be a tumour suppressor protein. The C22orf2 gene coding Chibby is located on chromosome 22, a region recurrently lost in colorectal cancer. Activation of the Wnt pathway is a major feature of colorectal cancer and occurs through inactivation of APC or activation of beta-catenin. All of this led us to analyse the possible implication of Chibby in colorectal carcinogenesis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenomatous Polyposis Coli Protein,
http://linkedlifedata.com/resource/pubmed/chemical/CBY1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15245581-Adenocarcinoma,
pubmed-meshheading:15245581-Adenomatous Polyposis Coli Protein,
pubmed-meshheading:15245581-Aged,
pubmed-meshheading:15245581-Base Sequence,
pubmed-meshheading:15245581-Carrier Proteins,
pubmed-meshheading:15245581-Chromosomes, Human, Pair 22,
pubmed-meshheading:15245581-Colorectal Neoplasms,
pubmed-meshheading:15245581-Cytoskeletal Proteins,
pubmed-meshheading:15245581-Female,
pubmed-meshheading:15245581-Gene Expression,
pubmed-meshheading:15245581-Genes, Tumor Suppressor,
pubmed-meshheading:15245581-Genotype,
pubmed-meshheading:15245581-Humans,
pubmed-meshheading:15245581-Loss of Heterozygosity,
pubmed-meshheading:15245581-Male,
pubmed-meshheading:15245581-Mutation,
pubmed-meshheading:15245581-Nuclear Proteins,
pubmed-meshheading:15245581-RNA, Neoplasm,
pubmed-meshheading:15245581-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15245581-Trans-Activators,
pubmed-meshheading:15245581-beta Catenin
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pubmed:year |
2004
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pubmed:articleTitle |
Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?
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pubmed:affiliation |
UMR-S Inserm 490, Laboratoire de Toxicologie Moléculaire, Université René Descartes-Paris V, 75006 Paris, France. Sophie.Gad@biomedicale.univ-paris5.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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