| pubmed-article:15243721 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15243721 | lifeskim:mentions | umls-concept:C0024467 | lld:lifeskim |
| pubmed-article:15243721 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:15243721 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15243721 | lifeskim:mentions | umls-concept:C1416548 | lld:lifeskim |
| pubmed-article:15243721 | lifeskim:mentions | umls-concept:C0289061 | lld:lifeskim |
| pubmed-article:15243721 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15243721 | pubmed:dateCreated | 2005-2-3 | lld:pubmed |
| pubmed-article:15243721 | pubmed:abstractText | We characterized the effects of intracellular Mg(2+) (Mg(2+) (i)) on potassium currents mediated by the Kv1.5 and Kv2.1 channels expressed in Xenopus oocytes. Increase in Mg(2+) (i) caused a voltage-dependent block of the current amplitude, apparent acceleration of the current kinetics (explained by a corresponding shift in the steady-state activation) and leftward shifts in activation and inactivation dependencies for both channels. The voltage-dependent block was more potent for Kv2.1 [dissociation constant at 0 mV, K(d)(0), was approximately 70 mM and the electric distance of the Mg(2+) binding site, delta, was 0.2] than for the Kv1.5 channel [K(d)(0) approximately 40 mM and delta = 0.1]. Similar shifts in the voltage-dependent parameters for both channels were described by the Gouy-Chapman formalism with the negative charge density of 1 e(-)/100 A(2). Additionally, Mg(2+) (i) selectively reduced a non-inactivating current and increased the accumulation of inactivation of the Kv1.5, but not the Kv2.1 channel. A potential functional role of the differential effects of Mg(2+) (i) on the Kv channels is discussed. | lld:pubmed |
| pubmed-article:15243721 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15243721 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15243721 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15243721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15243721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15243721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15243721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15243721 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15243721 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15243721 | pubmed:issn | 0175-7571 | lld:pubmed |
| pubmed-article:15243721 | pubmed:author | pubmed-author:SmirnovSergey... | lld:pubmed |
| pubmed-article:15243721 | pubmed:author | pubmed-author:TammaroPaoloP | lld:pubmed |
| pubmed-article:15243721 | pubmed:author | pubmed-author:MoranOscarO | lld:pubmed |
| pubmed-article:15243721 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15243721 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:15243721 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15243721 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15243721 | pubmed:pagination | 42-51 | lld:pubmed |
| pubmed-article:15243721 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:meshHeading | pubmed-meshheading:15243721... | lld:pubmed |
| pubmed-article:15243721 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15243721 | pubmed:articleTitle | Effects of intracellular magnesium on Kv1.5 and Kv2.1 potassium channels. | lld:pubmed |
| pubmed-article:15243721 | pubmed:affiliation | Department of Pharmacy and Pharmacology, University of Bath, Bath , BA2 7AY, UK. | lld:pubmed |
| pubmed-article:15243721 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15243721 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15243721 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15243721 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15243721 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15243721 | lld:pubmed |
