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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2004-7-9
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pubmed:abstractText |
Erythropoietin (EPO) increases the number of circulating erythrocytes primarily by preventing apoptosis of erythroid progenitors. In addition to this proerythroid action, results of recent studies show that systemically administered EPO is protective in vivo, in several animal models of neuronal injury. In vitro, EPO prevents neuronal apoptosis induced by a variety of stimuli. This review summarizes the neuroprotective actions of EPO and discusses the underlying mechanisms in terms of signal transduction pathways involved. The understanding of these mechanisms will help differentiate the neuroprotective actions of EPO from its role in the bone marrow.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Erythropoietin,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1350-9047
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S37-44
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15243580-Animals,
pubmed-meshheading:15243580-Anti-Inflammatory Agents,
pubmed-meshheading:15243580-Apoptosis,
pubmed-meshheading:15243580-Cytokines,
pubmed-meshheading:15243580-Cytoprotection,
pubmed-meshheading:15243580-DNA-Binding Proteins,
pubmed-meshheading:15243580-Endothelial Cells,
pubmed-meshheading:15243580-Epithelial Cells,
pubmed-meshheading:15243580-Erythropoietin,
pubmed-meshheading:15243580-Hematopoiesis,
pubmed-meshheading:15243580-Humans,
pubmed-meshheading:15243580-Hypoxia-Inducible Factor 1,
pubmed-meshheading:15243580-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:15243580-Inflammation,
pubmed-meshheading:15243580-Kidney Tubules,
pubmed-meshheading:15243580-Models, Biological,
pubmed-meshheading:15243580-Myocardial Ischemia,
pubmed-meshheading:15243580-Neurons,
pubmed-meshheading:15243580-Neuroprotective Agents,
pubmed-meshheading:15243580-Nuclear Proteins,
pubmed-meshheading:15243580-Signal Transduction,
pubmed-meshheading:15243580-Transcription Factors,
pubmed-meshheading:15243580-Trauma, Nervous System
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pubmed:year |
2004
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pubmed:articleTitle |
Erythropoietin as an antiapoptotic, tissue-protective cytokine.
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pubmed:affiliation |
Laboratory of Neuroimmunology, Mario Negri Institute, Milan, Italy. ghezzi@marionegri.it
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pubmed:publicationType |
Journal Article,
Review
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