| pubmed-article:15242757 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15242757 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15242757 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:15242757 | lifeskim:mentions | umls-concept:C0291573 | lld:lifeskim |
| pubmed-article:15242757 | lifeskim:mentions | umls-concept:C0205065 | lld:lifeskim |
| pubmed-article:15242757 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:15242757 | lifeskim:mentions | umls-concept:C0376571 | lld:lifeskim |
| pubmed-article:15242757 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:15242757 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15242757 | pubmed:dateCreated | 2004-7-9 | lld:pubmed |
| pubmed-article:15242757 | pubmed:abstractText | BRCA1 mutations have long been associated with altered apoptosis. We have recently reported that caspase 3 activation is increased in human ovarian surface epithelial (OSE) cells expressing a germline N-terminal BRCA1 185delAG mutation. Here, we report increased caspase 3 activity in 185delAG OSE cells associated with decreased expression of cIAP-1 and X-linked inhibitor of apoptosis (XIAP), and decreased ubiquitination of caspase 3. Overexpression of XIAP restored active caspase 3 ubiquitination and lowered levels of caspase 3 activity. Further, the BRCA1 185delAG mutation was associated with reduced levels of phosphorylated Akt1. Transfection with activated Akt1 led to increased cIAP-1 and XIAP levels similar to that seen in BRCA1 185delAG cell lines. Taken together, these data suggest a direct link between the BRCA1 185delAG mutation and alterations in the caspase-mediated apoptotic pathway. | lld:pubmed |
| pubmed-article:15242757 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15242757 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242757 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15242757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15242757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15242757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15242757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242757 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15242757 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15242757 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:15242757 | pubmed:author | pubmed-author:HagenK SKS | lld:pubmed |
| pubmed-article:15242757 | pubmed:author | pubmed-author:KrukPatricia... | lld:pubmed |
| pubmed-article:15242757 | pubmed:author | pubmed-author:ChengJin QJQ | lld:pubmed |
| pubmed-article:15242757 | pubmed:author | pubmed-author:JohnsonNicole... | lld:pubmed |
| pubmed-article:15242757 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15242757 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15242757 | pubmed:volume | 298 | lld:pubmed |
| pubmed-article:15242757 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15242757 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15242757 | pubmed:pagination | 9-16 | lld:pubmed |
| pubmed-article:15242757 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15242757 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15242757 | pubmed:articleTitle | BRCA1 185delAG mutation inhibits Akt-dependent, IAP-mediated caspase 3 inactivation in human ovarian surface epithelial cells. | lld:pubmed |
| pubmed-article:15242757 | pubmed:affiliation | University of South Florida College, Tampa 33612, USA. | lld:pubmed |
| pubmed-article:15242757 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15242757 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:672 | entrezgene:pubmed | pubmed-article:15242757 | lld:entrezgene |
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