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rdf:type |
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lifeskim:mentions |
umls-concept:C0005330,
umls-concept:C0017262,
umls-concept:C0023779,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0085542,
umls-concept:C0185117,
umls-concept:C0205054,
umls-concept:C0221102,
umls-concept:C0521378,
umls-concept:C1280500,
umls-concept:C1422255,
umls-concept:C1422256,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2004-7-9
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pubmed:abstractText |
Multidrug resistance associated gene product 2 (Mdr2) is believed to have a significant role in biliary cholesterol and phospholipid secretions. Both pravastatin and bezafibrate resulted in Mdr2 induction, but increased cholesterol secretion was observed only in pravastatin treatment. To explore the mechanism, the hepatic expression of genes that are responsible for the metabolism of the lipids was studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Abcg5 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Abcg8 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Bezafibrate,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Hypolipidemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pravastatin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance protein 3
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0815-9319
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Blackwell Publishing Asia Pty Ltd
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
879-83
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15242490-ATP-Binding Cassette Transporters,
pubmed-meshheading:15242490-Animals,
pubmed-meshheading:15242490-Bezafibrate,
pubmed-meshheading:15242490-Biliary Tract,
pubmed-meshheading:15242490-Biological Transport,
pubmed-meshheading:15242490-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:15242490-Hypolipidemic Agents,
pubmed-meshheading:15242490-Lipid Metabolism,
pubmed-meshheading:15242490-Lipoproteins,
pubmed-meshheading:15242490-Liver,
pubmed-meshheading:15242490-Male,
pubmed-meshheading:15242490-P-Glycoproteins,
pubmed-meshheading:15242490-Pravastatin,
pubmed-meshheading:15242490-RNA, Messenger,
pubmed-meshheading:15242490-Rats,
pubmed-meshheading:15242490-Rats, Sprague-Dawley,
pubmed-meshheading:15242490-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2004
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pubmed:articleTitle |
Effects of pravastatin and bezafibrate on biliary lipid excretion and hepatic expression of Abcg5 and Abcg8 in the rat.
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pubmed:affiliation |
Department of Hygiene, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan. kamisako@med.kindai.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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