| pubmed-article:15241725 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15241725 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15241725 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:15241725 | lifeskim:mentions | umls-concept:C0909868 | lld:lifeskim |
| pubmed-article:15241725 | lifeskim:mentions | umls-concept:C1563743 | lld:lifeskim |
| pubmed-article:15241725 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15241725 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15241725 | pubmed:dateCreated | 2004-7-8 | lld:pubmed |
| pubmed-article:15241725 | pubmed:abstractText | Following extensive suprasellar operations for excision of hypothalamic tumors, some patients develop morbid obesity despite receiving replacement doses of glucocorticoids. Urine analysis of cortisol and cortisone metabolites show that 11-OH/11-oxo ratios are significantly higher in patients with hypothalamic obesity, indicating enhanced 11beta-HSD1 activity. This correlates with the visceral-to-subcutaneous fat ratio. The consequence of increased 11beta-HSD1 activity and a shift of the steroid inter-conversion towards cortisol may contribute to the effects of the latter in adipose tissue. The message from the hypothalamus to adipocyte 11beta-HSD-1 involves hormones, the sympathetic nervous system and cytokines. CRH and ACTH downregulate 11beta-HSD-1 activity and induce lipolysis. Tumor necrosis factor-alpha and interleukin-1beta upregulate 11beta-HSD-1 expression and activity, while enhancing lipolysis. The sympathetic nervous system exerts its effects through beta-adrenergic upregulation and alpha-adrenergic downregulation of 11beta-HSD-1 activity. Inhibition of 11beta-HSD-1 suppresses preadipocyte differentiation into mature adipocytes, and may provide a therapeutic tool. | lld:pubmed |
| pubmed-article:15241725 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15241725 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15241725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15241725 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15241725 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15241725 | pubmed:issn | 0018-5043 | lld:pubmed |
| pubmed-article:15241725 | pubmed:author | pubmed-author:FriedbergMM | lld:pubmed |
| pubmed-article:15241725 | pubmed:author | pubmed-author:BadenHH | lld:pubmed |
| pubmed-article:15241725 | pubmed:author | pubmed-author:HochbergZZ | lld:pubmed |
| pubmed-article:15241725 | pubmed:author | pubmed-author:TiosanoDD | lld:pubmed |
| pubmed-article:15241725 | pubmed:author | pubmed-author:YanivLL | lld:pubmed |
| pubmed-article:15241725 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15241725 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:15241725 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15241725 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15241725 | pubmed:pagination | 365-9 | lld:pubmed |
| pubmed-article:15241725 | pubmed:dateRevised | 2009-2-19 | lld:pubmed |
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| pubmed-article:15241725 | pubmed:meshHeading | pubmed-meshheading:15241725... | lld:pubmed |
| pubmed-article:15241725 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15241725 | pubmed:articleTitle | Hypothalamic regulation of adiposity: the role of 11beta-hydroxysteroid dehydrogenase type 1. | lld:pubmed |
| pubmed-article:15241725 | pubmed:affiliation | Division of Endocrinology, Meyer Children's Hospital, PO Box 9602, Rambam Medical Center, Haifa 31096, Israel. z_hochberg@rambam.health.gov.il | lld:pubmed |
| pubmed-article:15241725 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15241725 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15241725 | lld:pubmed |
