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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-7-8
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pubmed:abstractText |
Following extensive suprasellar operations for excision of hypothalamic tumors, some patients develop morbid obesity despite receiving replacement doses of glucocorticoids. Urine analysis of cortisol and cortisone metabolites show that 11-OH/11-oxo ratios are significantly higher in patients with hypothalamic obesity, indicating enhanced 11beta-HSD1 activity. This correlates with the visceral-to-subcutaneous fat ratio. The consequence of increased 11beta-HSD1 activity and a shift of the steroid inter-conversion towards cortisol may contribute to the effects of the latter in adipose tissue. The message from the hypothalamus to adipocyte 11beta-HSD-1 involves hormones, the sympathetic nervous system and cytokines. CRH and ACTH downregulate 11beta-HSD-1 activity and induce lipolysis. Tumor necrosis factor-alpha and interleukin-1beta upregulate 11beta-HSD-1 expression and activity, while enhancing lipolysis. The sympathetic nervous system exerts its effects through beta-adrenergic upregulation and alpha-adrenergic downregulation of 11beta-HSD-1 activity. Inhibition of 11beta-HSD-1 suppresses preadipocyte differentiation into mature adipocytes, and may provide a therapeutic tool.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0018-5043
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
365-9
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pubmed:dateRevised |
2009-2-19
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pubmed:meshHeading |
pubmed-meshheading:15241725-11-beta-Hydroxysteroid Dehydrogenase Type 1,
pubmed-meshheading:15241725-Adipocytes,
pubmed-meshheading:15241725-Adipose Tissue,
pubmed-meshheading:15241725-Cortisone,
pubmed-meshheading:15241725-Enzyme Activation,
pubmed-meshheading:15241725-Gene Expression Regulation,
pubmed-meshheading:15241725-Humans,
pubmed-meshheading:15241725-Hydrocortisone,
pubmed-meshheading:15241725-Hypothalamus,
pubmed-meshheading:15241725-Interleukin-1,
pubmed-meshheading:15241725-Interleukin-1beta,
pubmed-meshheading:15241725-Lipolysis,
pubmed-meshheading:15241725-Obesity,
pubmed-meshheading:15241725-Peptide Fragments,
pubmed-meshheading:15241725-Signal Transduction,
pubmed-meshheading:15241725-Sympathetic Nervous System,
pubmed-meshheading:15241725-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Hypothalamic regulation of adiposity: the role of 11beta-hydroxysteroid dehydrogenase type 1.
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pubmed:affiliation |
Division of Endocrinology, Meyer Children's Hospital, PO Box 9602, Rambam Medical Center, Haifa 31096, Israel. z_hochberg@rambam.health.gov.il
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pubmed:publicationType |
Journal Article,
Review
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