Linked Life Data

15240898

Source:http://linkedlifedata.com/resource/pubmed/id/15240898

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
240
pubmed:dateCreated
2004-7-8
pubmed:abstractText
This animation provides an interactive presentation of the Wnt signaling pathway as it may occur in multiple cell types. This animation would be useful in teaching developmental biology, immunology, and cell signaling courses. Activation of Wnt pathways can modulate cell proliferation, cell survival, cell behavior, and cell fate. In the basal, unstimulated state in the absence of ligand, there is a constitutively active kinase, which phosphorylates target proteins, resulting in their degradation. Thus, the presence of the ligand Wnt inactivates the kinase allowing accumulation of beta-catenin, which then translocates to the nucleus and acts as a transcriptional regulator.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1525-8882
pubmed:author
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
2004
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
tr5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Teaching resource. Canonical Wnt/beta-catenin signaling.
pubmed:affiliation
Howard Hughes Medical Institute and Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA. rtmoon@u.washington.edu
pubmed:publicationType
Journal Article