Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-7-8
pubmed:abstractText
The structures of two response regulators (RRs) from the cyanobacterium Calothrix PCC7601, RcpA and RcpB, were solved to 1.9- and 1.75-A resolution, respectively. RcpA was found in phosphorylated and RcpB in nonphosphorylated form. Both RRs are members of phytochrome-associated, light-sensing two-component signal transduction pathways, based on histidine kinase-mediated receptor autophosphorylation and phosphorelay to a RR. Despite the overall folding similarity to CheY-type RRs ((beta/alpha)(5)-motif), RcpA and RcpB form homodimers, irrespective of their phosphorylation state, giving insight into a signal transduction putatively different from that of other known RRs. Dimerization is accomplished by a C-terminal extension of the RR polypeptide chain, and the surface formed by H4, beta 5, and H5, which constitute a hydrophobic contact area with distinct interactions between residues of either subunit. Sequence alignments reveal that the identified dimerization motif is archetypal for phytochrome-associated RRs, making them a novel subgroup of CheY-type RRs. The protein structures of RcpA and RcpB are compared to the recently presented protein structure of Rcp1 from Synechocystis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-10089488, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-10331874, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-10411503, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-10556024, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-10617469, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-10754569, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-10837243, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-10966457, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-11029065, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-11135671, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-11277928, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-11279165, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-11369279, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-11422367, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-11847283, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-12047374, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-12081331, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-15299374, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-15299543, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-2025413, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-2645526, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-7989325, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-8176739, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-9109482, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-9115243, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-9241419, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-9278513, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-9295320, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-9335530, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-9437425, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-9657998, http://linkedlifedata.com/resource/pubmed/commentcorrection/15240481-9757107
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-3495
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
476-87
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Crystal structures of two cyanobacterial response regulators in apo- and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators.
pubmed:affiliation
Max-Planck-Institut für Biochemie, D-82152 Martinsried, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't