|
rdf:type |
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lifeskim:mentions |
umls-concept:C0024518,
umls-concept:C0030956,
umls-concept:C0086418,
umls-concept:C0178784,
umls-concept:C0205227,
umls-concept:C0301872,
umls-concept:C0449255,
umls-concept:C0449450,
umls-concept:C0456387,
umls-concept:C0520484,
umls-concept:C0567416,
umls-concept:C1135183
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|
pubmed:issue |
10
|
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pubmed:dateCreated |
2004-7-8
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|
pubmed:abstractText |
Porcine endogenous retroviruses (PERV) have been shown to infect human cells, raising concerns regarding safety of xenotransplantation. In patients exposed to porcine tissues, no PERV infection has been observed. This study was designed to develop human CD8+ cytotoxic T lymphocytes (CTL) against PERV-derived peptides presented in the context of human leukocyte antigen (HLA) or swine leukocyte antigen (SLA) class I molecules and to define dominant epitopes contributed by PERV.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
|
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pubmed:issn |
0041-1337
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
27
|
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pubmed:volume |
77
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1580-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15239626-Animals,
pubmed-meshheading:15239626-Antibody Formation,
pubmed-meshheading:15239626-Aorta,
pubmed-meshheading:15239626-Cell Line,
pubmed-meshheading:15239626-Endothelium, Vascular,
pubmed-meshheading:15239626-Epitopes,
pubmed-meshheading:15239626-HLA-A2 Antigen,
pubmed-meshheading:15239626-Histocompatibility Antigens Class I,
pubmed-meshheading:15239626-Histocompatibility Antigens Class II,
pubmed-meshheading:15239626-Humans,
pubmed-meshheading:15239626-Immunodominant Epitopes,
pubmed-meshheading:15239626-Organ Transplantation,
pubmed-meshheading:15239626-Peptides,
pubmed-meshheading:15239626-Retroviridae,
pubmed-meshheading:15239626-Swine,
pubmed-meshheading:15239626-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:15239626-Transplantation, Heterologous,
pubmed-meshheading:15239626-Viral Envelope Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Human immune responses to porcine endogenous retrovirus-derived peptides presented naturally in the context of porcine and human major histocompatibility complex class I molecules: implications in xenotransplantation of porcine organs.
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pubmed:affiliation |
Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
