Source:http://linkedlifedata.com/resource/pubmed/id/15239588
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2004-7-8
|
| pubmed:abstractText |
To investigate whether the caudal ventrolateral medulla (CVLM) participates in the regulation of gallbladder motility, we studied the effects of microinjection of L-glutamate and other agents into the CVLM on gallbladder pressure (GP) in anesthetized rabbits. A frog bladder connected with a force transducer was inserted into the gallbladder to record the change of GP. Microinjection of L-glutamate into the CVLM decreased GP, While micnoinjection of gamma-amino-butyric acid (GABA) increased GP. Microinjection of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, into CVLM increased GP, while microinjection of 6-cyano-7-nitroquinoxaline-2,3-(1H,4H)-dione (CNQX), a competitive (+/-)-a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist, had no significant effect on GP. The effects of L-glutamate was abolished by ketamine, but not by CNQX. Intravenous injection of phentolamine or transection of the spinal cord eliminated the effects of L-glutamate on GP. These results indicate that [1] CVLM participated in the regulation of gallbladder motility; [2] endogenous L-glutamate in CVLM is involved in the regulation mediated by NMDA receptors, the output of which is sent through sympathetic nerve and alpha-adrenergic receptors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ketamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0304-4920
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
31
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-6
|
| pubmed:dateRevised |
2009-8-12
|
| pubmed:meshHeading |
pubmed-meshheading:15239588-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:15239588-Animals,
pubmed-meshheading:15239588-Anura,
pubmed-meshheading:15239588-Excitatory Amino Acid Antagonists,
pubmed-meshheading:15239588-Female,
pubmed-meshheading:15239588-Gallbladder,
pubmed-meshheading:15239588-Gallbladder Emptying,
pubmed-meshheading:15239588-Glutamic Acid,
pubmed-meshheading:15239588-Ketamine,
pubmed-meshheading:15239588-Male,
pubmed-meshheading:15239588-Medulla Oblongata,
pubmed-meshheading:15239588-Microinjections,
pubmed-meshheading:15239588-Neural Pathways,
pubmed-meshheading:15239588-Pressure,
pubmed-meshheading:15239588-Rabbits,
pubmed-meshheading:15239588-Receptors, AMPA,
pubmed-meshheading:15239588-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:15239588-Sympathetic Nervous System,
pubmed-meshheading:15239588-gamma-Aminobutyric Acid
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Participation of caudal ventrolateral medulla in the regulation of gallbladder motility in rabbits.
|
| pubmed:affiliation |
Department of Physiology, School of Medicine, Shanldong University, Jinan 250012, Shandong Province, PR China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|