Linked Life Data

1523844

Source:http://linkedlifedata.com/resource/pubmed/id/1523844

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1992-10-9
pubmed:abstractText
The efficacy of a single intracutaneous BCG injection in prevention of recurrent herpes simplex (HS) was investigated in Tine-test-negative people. Most patients had a recurrence rate of HS of at least once per month. Between 1976 and 1983 109 patients were BCG-vaccinated (BCG sec Berna). Tine-test was negative in all subjects and converted to positive in 106 out of 109 patients after vaccination. Patients suffered from HS for many years and thus acted as their own controls comparing them before and after BCG. After vaccination all patients remained herpes-free for at least 4-6 months. In a separate study a follow-up up to 10 years was done. This showed a decreasing effect of BCG over the years with still 21 (19%) completely herpes-free patients after 3 years. 10 patients (9%) even had been free of herpes for more than 6 years. Reduction of frequency and duration of HS after BCG was statistically significant (p less than 0.01). Since the BCG vaccination can be assumed to be virtually without risk, a Tine-test followed by BCG vaccination should be considered as treatment of choice in patients with recurrent HS for prevention of recurrences.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0043-5325
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
200-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
[Nonspecific immune stimulation with BCG in Herpes simplex recidivans. Follow-up 5 to 10 years after BCG vaccination].
pubmed:affiliation
Dermatologisches und Pädiatrisches Allergieambulatorium, Wien.
pubmed:publicationType
Journal Article, English Abstract