Linked Life Data

15236867

Source:http://linkedlifedata.com/resource/pubmed/id/15236867

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-7-6
pubmed:abstractText
Histaminergic neurons have been strongly implicated in the regulation of wakefulness by activating cortical neurons. However, little is known about histamine release in the cortex during sleep-wake stages. In this study, we monitored the extracellular histamine level in the frontal cortex by in vivo microdialysis coupled with electroencephalogram and electromyogram recordings in freely moving rats. The histamine release was 3.8 times higher during wake episodes than during sleep episodes, being positively correlated (r = 0.845) with the time spent in wakefulness. These findings indicate that the histamine release in the cortex is strongly related to the sleep-wake cycle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0168-0102
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
417-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats.
pubmed:affiliation
Department of Pharmacology, Shanghai Medical College of Fudan University, Shanghai 200032, PR China
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't