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pubmed:abstractText |
The stromal component of the thymic microenvironment is critical for T lymphocyte generation. Thymocyte differentiation involves a cascade of coordinated stromal genes controlling thymocyte survival, lineage commitment and selection. The "Stromal Protein Associated with Thymii And Lymph-node" (Spatial) gene encodes a putative transcription factor which may be involved in T-cell development. In the testis, the Spatial gene is also expressed by round spermatids during spermatogenesis.
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pubmed:affiliation |
ERM 0206 INSERM, Case 928, Parc Scientifique de Luminy, F-13288 Marseille Cedex 9, Université de la méditerranée, faculté de science de Luminy, France. irla@tagc.univ-mrs.fr
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