| pubmed-article:15236231 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15236231 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:15236231 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:15236231 | lifeskim:mentions | umls-concept:C0034143 | lld:lifeskim |
| pubmed-article:15236231 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:15236231 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15236231 | pubmed:dateCreated | 2004-7-5 | lld:pubmed |
| pubmed-article:15236231 | pubmed:abstractText | The number of cerebellar Purkinje cells is increased by over 40% in young transgenic mice that overexpress a human Bcl-2 transgene (Hu-Bcl-2). To determine whether the Bcl-2-mediated rescue of Purkinje cells persists through life, the numbers of Purkinje cells were estimated in 6-, 12-, 18-, and 24-month-old Hu-Bcl-2 transgenic mice and age-matched controls. In addition, the expression of four markers for Purkinje cell differentiation, calbindin (CaBP), the 67-kDa isoform of glutamic acid decarboxylase (GAD67), gamma-aminobutyric acid transaminase (GABA-T), and the NMDA-R1 receptor subtype (NMDA-NR1) was analyzed in 6-month-old Hu-Bcl-2 transgenics and controls to determine whether overexpression of Bcl-2 and rescue from naturally occurring cell death affects the normal differentiation of Purkinje cells. The estimates of Purkinje cell numbers showed that the number of Purkinje cells in the Hu-Bcl-2 transgenics declines after 6 months to approach wild-type values by 18 months. Although the exogenous human BCL-2 is still expressed in Purkinje cells at 24 months, the expression levels of human BCL-2 appear to decline significantly after 6 months, suggesting that survival of the supernumary Purkinje cells depends on the sustained overexpression of Bcl-2. All the Purkinje cells in the Hu-Bcl-2 transgenic mice appeared to express normal levels of the differentiation markers analyzed so there was no evidence for a class of Purkinje cells that do not differentiate normally when rescued from naturally occurring cell death. | lld:pubmed |
| pubmed-article:15236231 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15236231 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15236231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15236231 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15236231 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15236231 | pubmed:issn | 0021-9967 | lld:pubmed |
| pubmed-article:15236231 | pubmed:author | pubmed-author:Lemaigre-Dubr... | lld:pubmed |
| pubmed-article:15236231 | pubmed:author | pubmed-author:ZanjaniHadiH | lld:pubmed |
| pubmed-article:15236231 | pubmed:author | pubmed-author:MarianiJeanJ | lld:pubmed |
| pubmed-article:15236231 | pubmed:author | pubmed-author:McMahonRobert... | lld:pubmed |
| pubmed-article:15236231 | pubmed:author | pubmed-author:TillakaratneN... | lld:pubmed |
| pubmed-article:15236231 | pubmed:author | pubmed-author:TobinAllan... | lld:pubmed |
| pubmed-article:15236231 | pubmed:author | pubmed-author:VogelMichael... | lld:pubmed |
| pubmed-article:15236231 | pubmed:author | pubmed-author:BlokhinAndrei... | lld:pubmed |
| pubmed-article:15236231 | pubmed:copyrightInfo | Copyright 2004 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:15236231 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15236231 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:15236231 | pubmed:volume | 475 | lld:pubmed |
| pubmed-article:15236231 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15236231 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15236231 | pubmed:pagination | 481-92 | lld:pubmed |
| pubmed-article:15236231 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:meshHeading | pubmed-meshheading:15236231... | lld:pubmed |
| pubmed-article:15236231 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15236231 | pubmed:articleTitle | Cerebellar Purkinje cell loss in aging Hu-Bcl-2 transgenic mice. | lld:pubmed |
| pubmed-article:15236231 | pubmed:affiliation | Lab. Développement et Vieillissement du Système Nerveux (DVSN), UMR NPA 7102 Centre National de la Recherche Scientifique and Université Pierre and Marie Curie, 75005 Paris, France. | lld:pubmed |
| pubmed-article:15236231 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15236231 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15236231 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15236231 | lld:pubmed |
