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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-8-2
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pubmed:abstractText |
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
813-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15235599-Animals,
pubmed-meshheading:15235599-Corneal Transplantation,
pubmed-meshheading:15235599-Dendritic Cells,
pubmed-meshheading:15235599-Flow Cytometry,
pubmed-meshheading:15235599-Gene Expression Regulation,
pubmed-meshheading:15235599-Glycoproteins,
pubmed-meshheading:15235599-Graft Rejection,
pubmed-meshheading:15235599-Humans,
pubmed-meshheading:15235599-Hypersensitivity, Delayed,
pubmed-meshheading:15235599-Keratitis,
pubmed-meshheading:15235599-Lymphangiogenesis,
pubmed-meshheading:15235599-Mice,
pubmed-meshheading:15235599-Microscopy, Fluorescence,
pubmed-meshheading:15235599-Models, Animal,
pubmed-meshheading:15235599-Signal Transduction,
pubmed-meshheading:15235599-Vascular Endothelial Growth Factor C,
pubmed-meshheading:15235599-Vascular Endothelial Growth Factor Receptor-3,
pubmed-meshheading:15235599-Vesicular Transport Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity.
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pubmed:affiliation |
Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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