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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-7-2
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pubmed:abstractText |
To elucidate the roles of LH2b in collagen cross-linking, MC3T3-E1 cell clones expressing higher (S) or lower (AS) levels of LH2b were established. Compared with controls, the collagen cross-linking pattern was shifted toward hydroxylysine-aldehyde (S clones)- or lysine-aldehyde (AS clones)-derived pathways. The data indicate that LH2b directs collagen cross-linking pathways through its action on telopeptidyl lysine residues.
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pubmed:grant |
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pubmed:keyword |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,5'-dihydroxylysylnorleucine,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Desmosine,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Histidine,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lysine,
http://linkedlifedata.com/resource/pubmed/chemical/Procollagen-Lysine, 2-Oxoglutarate...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/dehydrohistidinohydroxymerodesmosine,
http://linkedlifedata.com/resource/pubmed/chemical/delta-hydroxylysylnorleucine,
http://linkedlifedata.com/resource/pubmed/chemical/histidinohydroxymerodesmosine,
http://linkedlifedata.com/resource/pubmed/chemical/pyridinoline
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1349-55
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15231023-3T3 Cells,
pubmed-meshheading:15231023-Amino Acids,
pubmed-meshheading:15231023-Animals,
pubmed-meshheading:15231023-Blotting, Western,
pubmed-meshheading:15231023-Collagen,
pubmed-meshheading:15231023-DNA, Antisense,
pubmed-meshheading:15231023-DNA, Complementary,
pubmed-meshheading:15231023-Desmosine,
pubmed-meshheading:15231023-Dipeptides,
pubmed-meshheading:15231023-Gene Expression,
pubmed-meshheading:15231023-Genetic Vectors,
pubmed-meshheading:15231023-Histidine,
pubmed-meshheading:15231023-Immunoprecipitation,
pubmed-meshheading:15231023-Isoenzymes,
pubmed-meshheading:15231023-Lysine,
pubmed-meshheading:15231023-Mice,
pubmed-meshheading:15231023-Osteoblasts,
pubmed-meshheading:15231023-Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase,
pubmed-meshheading:15231023-Protein Processing, Post-Translational,
pubmed-meshheading:15231023-RNA,
pubmed-meshheading:15231023-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15231023-Transfection
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pubmed:year |
2004
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pubmed:articleTitle |
Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells.
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pubmed:affiliation |
Dental Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7455, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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