Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-7-2
pubmed:abstractText
The coordination of cell cycle progression and osteoclast differentiation by RANKL signaling was studied. Experiments with mouse genetic models revealed that RANKL promoted cell cycle withdrawal of osteoclast precursors dependent on the cyclin kinase inhibitor p27-KIP1, but that both p27-KIP1 and p21-CIP1 were required for osteoclast differentiation. These cyclin inhibitors may directly regulate osteoclast differentiation in addition to regulating cell cycle withdrawal.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz..., http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase, http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase, http://linkedlifedata.com/resource/pubmed/chemical/CDC2-CDC28 Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin K, http://linkedlifedata.com/resource/pubmed/chemical/Cathepsins, http://linkedlifedata.com/resource/pubmed/chemical/Cdk2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1b protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cdkn2c protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cdkn2d protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Chromones, http://linkedlifedata.com/resource/pubmed/chemical/Ctsk protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 2, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Colony-Stimulating Factor, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Morpholines, http://linkedlifedata.com/resource/pubmed/chemical/PD 98059, http://linkedlifedata.com/resource/pubmed/chemical/Pyridines, http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand, http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear..., http://linkedlifedata.com/resource/pubmed/chemical/SB 203580, http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11a protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf11 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0884-0431
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1339-48
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15231022-Animals, pubmed-meshheading:15231022-Mice, pubmed-meshheading:15231022-Pyridines, pubmed-meshheading:15231022-Imidazoles, pubmed-meshheading:15231022-Femur, pubmed-meshheading:15231022-Alkaline Phosphatase, pubmed-meshheading:15231022-Osteopetrosis, pubmed-meshheading:15231022-Acid Phosphatase, pubmed-meshheading:15231022-Morpholines, pubmed-meshheading:15231022-Cathepsins, pubmed-meshheading:15231022-Osteoclasts, pubmed-meshheading:15231022-Enzyme Inhibitors, pubmed-meshheading:15231022-Flavonoids, pubmed-meshheading:15231022-Chromones, pubmed-meshheading:15231022-Macrophages, pubmed-meshheading:15231022-Cells, Cultured, pubmed-meshheading:15231022-Cell Differentiation, pubmed-meshheading:15231022-Bone Marrow Cells, pubmed-meshheading:15231022-Isoenzymes, pubmed-meshheading:15231022-Mice, Inbred C57BL, pubmed-meshheading:15231022-Cell Cycle, pubmed-meshheading:15231022-Carrier Proteins, pubmed-meshheading:15231022-Cell Proliferation, pubmed-meshheading:15231022-Membrane Glycoproteins, pubmed-meshheading:15231022-Gene Expression, pubmed-meshheading:15231022-Tumor Suppressor Proteins, pubmed-meshheading:15231022-Blotting, Western, pubmed-meshheading:15231022-Cathepsin K, pubmed-meshheading:15231022-Cell Cycle Proteins, pubmed-meshheading:15231022-Mice, Knockout, pubmed-meshheading:15231022-Macrophage Colony-Stimulating Factor
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