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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-7-2
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pubmed:abstractText |
The absence of the wildtype allele of a promoter polymorphism of the IGF-I gene is associated with increased risk (1.5; 95% CI, 1.1-2.0) of fragility fracture in women (n = 4212) but not in men (n = 2799). An approximation of hip bone geometry (from DXA) suggested the polymorphism is associated with bone strength and stability in gender-specific ways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1280-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15231015-Aged,
pubmed-meshheading:15231015-Aged, 80 and over,
pubmed-meshheading:15231015-Body Mass Index,
pubmed-meshheading:15231015-Bone Density,
pubmed-meshheading:15231015-Female,
pubmed-meshheading:15231015-Femur Neck,
pubmed-meshheading:15231015-Fractures, Bone,
pubmed-meshheading:15231015-Gene Frequency,
pubmed-meshheading:15231015-Genotype,
pubmed-meshheading:15231015-Heterozygote,
pubmed-meshheading:15231015-Hip Fractures,
pubmed-meshheading:15231015-Homozygote,
pubmed-meshheading:15231015-Humans,
pubmed-meshheading:15231015-Insulin-Like Growth Factor I,
pubmed-meshheading:15231015-Male,
pubmed-meshheading:15231015-Middle Aged,
pubmed-meshheading:15231015-Netherlands,
pubmed-meshheading:15231015-Pelvic Bones,
pubmed-meshheading:15231015-Polymorphism, Genetic,
pubmed-meshheading:15231015-Promoter Regions, Genetic,
pubmed-meshheading:15231015-Proportional Hazards Models,
pubmed-meshheading:15231015-Prospective Studies,
pubmed-meshheading:15231015-Risk Factors,
pubmed-meshheading:15231015-Sex Factors,
pubmed-meshheading:15231015-Shoulder Fractures,
pubmed-meshheading:15231015-Wrist Injuries
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pubmed:year |
2004
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pubmed:articleTitle |
The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: the Rotterdam Study.
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pubmed:affiliation |
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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