| pubmed-article:15229812 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15229812 | lifeskim:mentions | umls-concept:C1135978 | lld:lifeskim |
| pubmed-article:15229812 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:15229812 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15229812 | lifeskim:mentions | umls-concept:C1516463 | lld:lifeskim |
| pubmed-article:15229812 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15229812 | pubmed:dateCreated | 2004-7-1 | lld:pubmed |
| pubmed-article:15229812 | pubmed:abstractText | A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aalpha,12aalpha-12a-hydroxyelliptone ( 3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of beta-carotene without any cytotoxicity. Deguelin ( 4) and alpha-toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters. | lld:pubmed |
| pubmed-article:15229812 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15229812 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15229812 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15229812 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15229812 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15229812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15229812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15229812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15229812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15229812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15229812 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15229812 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15229812 | pubmed:issn | 0032-0943 | lld:pubmed |
| pubmed-article:15229812 | pubmed:author | pubmed-author:ItoigawaMasat... | lld:pubmed |
| pubmed-article:15229812 | pubmed:author | pubmed-author:ItoChihiroC | lld:pubmed |
| pubmed-article:15229812 | pubmed:author | pubmed-author:TokudaHarukun... | lld:pubmed |
| pubmed-article:15229812 | pubmed:author | pubmed-author:NishinoHoyoku... | lld:pubmed |
| pubmed-article:15229812 | pubmed:author | pubmed-author:FurukawaHiros... | lld:pubmed |
| pubmed-article:15229812 | pubmed:author | pubmed-author:TakayasuJunko... | lld:pubmed |
| pubmed-article:15229812 | pubmed:author | pubmed-author:KojimaNaokiN | lld:pubmed |
| pubmed-article:15229812 | pubmed:author | pubmed-author:TanHugh T-WHT | lld:pubmed |
| pubmed-article:15229812 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15229812 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:15229812 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15229812 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15229812 | pubmed:pagination | 585-8 | lld:pubmed |
| pubmed-article:15229812 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15229812 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15229812 | pubmed:articleTitle | Cancer chemopreventive activity of rotenoids from Derris trifoliata. | lld:pubmed |
| pubmed-article:15229812 | pubmed:affiliation | Faculty of Pharmacy, Meijo University, Nagoya, Japan. | lld:pubmed |
| pubmed-article:15229812 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15229812 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15229812 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15229812 | pubmed:publicationType | Corrected and Republished Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15229812 | lld:pubmed |
