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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-7-1
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pubmed:abstractText |
A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aalpha,12aalpha-12a-hydroxyelliptone ( 3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of beta-carotene without any cytotoxicity. Deguelin ( 4) and alpha-toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Epstein-Barr virus early antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Rotenone,
http://linkedlifedata.com/resource/pubmed/chemical/beta Carotene,
http://linkedlifedata.com/resource/pubmed/chemical/deguelin,
http://linkedlifedata.com/resource/pubmed/chemical/elliptone
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0032-0943
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
585-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15229812-Animals,
pubmed-meshheading:15229812-Antigens, Viral,
pubmed-meshheading:15229812-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:15229812-Benzopyrans,
pubmed-meshheading:15229812-Cell Line,
pubmed-meshheading:15229812-Fabaceae,
pubmed-meshheading:15229812-Female,
pubmed-meshheading:15229812-Herpesvirus 4, Human,
pubmed-meshheading:15229812-Humans,
pubmed-meshheading:15229812-Mice,
pubmed-meshheading:15229812-Mice, Inbred ICR,
pubmed-meshheading:15229812-Papilloma,
pubmed-meshheading:15229812-Phytotherapy,
pubmed-meshheading:15229812-Plant Extracts,
pubmed-meshheading:15229812-Plant Stems,
pubmed-meshheading:15229812-Rotenone,
pubmed-meshheading:15229812-Skin Neoplasms,
pubmed-meshheading:15229812-Virus Activation,
pubmed-meshheading:15229812-beta Carotene
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pubmed:year |
2004
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pubmed:articleTitle |
Cancer chemopreventive activity of rotenoids from Derris trifoliata.
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pubmed:affiliation |
Faculty of Pharmacy, Meijo University, Nagoya, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Corrected and Republished Article
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