Source:http://linkedlifedata.com/resource/pubmed/id/15228210
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2004-7-1
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| pubmed:abstractText |
We studied non-hospitalized 30-69 y-old Japanese subjects to ascertain the influences of a 677C-T methylene-tetrahydrofolate reductase (MTHFR) genotype, nutritional intake and lifestyle-related factors on plasma homocysteine (Hcys) and serum folate concentrations. Hcys was higher and serum folate was lower in males than in females (p < .01). The Hcys concentration was higher in the VV group than in the AA and AV groups for both males and females. However, a relatively low serum folate concentration of 18 +/- 7 nmol/L was found in the entire male group as compared with 22 +/- 10 nmol/L in all females. In the female subjects, serum folate concentrations differed among MTHFR genotypes, being lowest in the VV group. In all male subjects, log folate intake per 1,000 kcal was a significant positive predictor of log serum folate concentration (p < 0.01), while in females the log vitamin C intake per standard body weight was a significant positive variable (p < 0.001) predicting the log serum folate concentration. Smokers had significantly lower serum folate concentrations, regardless of dietary folate intake. High folate and vitamin C consumptions, appears to be beneficial to normal and heterozygous MTHFR genotype subjects for maintaining serum folate concentrations. Even a 400 microg daily intake of folate might be less than what is needed, especially for homozygous MTHFR subjects and smokers, to maintain an adequate serum folate concentration.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Homocysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Methylenetetrahydrofolate...,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin B Complex
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
0301-4800
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| pubmed:author |
pubmed-author:ArakiRisaR,
pubmed-author:IwasawaAkikoA,
pubmed-author:KuniyoshiErikoE,
pubmed-author:KyotaniShingoS,
pubmed-author:MaruyamaChizukoC,
pubmed-author:MaruyamaTaroT,
pubmed-author:MotohashiYoshikoY,
pubmed-author:NakanishiMamoruM,
pubmed-author:NakanoSatomiS,
pubmed-author:TakeuchiMayakoM,
pubmed-author:TsushimaMotooM
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| pubmed:issnType |
Print
|
| pubmed:volume |
50
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-8
|
| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15228210-Adult,
pubmed-meshheading:15228210-Aged,
pubmed-meshheading:15228210-Alcohol Drinking,
pubmed-meshheading:15228210-Ascorbic Acid,
pubmed-meshheading:15228210-Diet,
pubmed-meshheading:15228210-Female,
pubmed-meshheading:15228210-Folic Acid,
pubmed-meshheading:15228210-Genotype,
pubmed-meshheading:15228210-Homocysteine,
pubmed-meshheading:15228210-Humans,
pubmed-meshheading:15228210-Japan,
pubmed-meshheading:15228210-Life Style,
pubmed-meshheading:15228210-Male,
pubmed-meshheading:15228210-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:15228210-Middle Aged,
pubmed-meshheading:15228210-Nutritional Physiological Phenomena,
pubmed-meshheading:15228210-Polymorphism, Genetic,
pubmed-meshheading:15228210-Sex Characteristics,
pubmed-meshheading:15228210-Smoking,
pubmed-meshheading:15228210-Vitamin B Complex
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| pubmed:year |
2004
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| pubmed:articleTitle |
Relationships of nutrient intake and lifestyle-related factors to serum folate and plasma homocysteine concentrations in 30-69 year-old Japanese.
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| pubmed:affiliation |
Department of Food and Nutrition, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo 112-8681, Japan. maruyama@fc.jwu.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|