Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-6-30
pubmed:abstractText
Control of the cell surface allows modulation of the cell's biological response, producing practical applications and satisfying scientific interests. Consequently, to meet such goals and interests, diverse approaches were developed in cell surface engineering techniques. Poly(ethylene glycol) (PEG) intermediates were widely employed to modify proteins, enzymes, artificial surfaces, liposomes, and drugs for practical usage. PEGylation was also used for modification of cell surface properties. A method was recently developed for the rapid incorporation of proteins into mammalian cell membranes using lipid-PEG(n) derivatives under physiological conditions. This is a rapid and homogeneous method to incorporate lipid-PEG(n), which was used as a model to study the modification of cellular properties and cell-cell interactions. Because the stability of molecules incorporated into the cell surface shows the usefulness of the anchoring technique, it was also investigated whether potential factors such as time, the concentration of the incorporated lipid-PEG(n), and the type of medium affect this incorporation. At concentrations greater than 10 microM, when dual typed lipid-PEG(n) was incorporated into erythrocytes, antigenic recognition was dramatically attenuated, resulting in the successful development of stealth cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1549-3296
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 179-185, 2004
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Casual cell surface remodeling using biocompatible lipid-poly(ethylene glycol)(n): development of stealth cells and monitoring of cell membrane behavior in serum-supplemented conditions.
pubmed:affiliation
Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, 1-3-7 Hongo, Bunkyo, Tokyo 113-8656, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't