Linked Life Data

15227178

Source:http://linkedlifedata.com/resource/pubmed/id/15227178

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-6-30
pubmed:abstractText
Three patients developed quinidine-induced thrombocytopenia within 3 months of our initiating quinidine therapy after open-heart surgery. One patient recovered from thrombocytopenic purpura after quinidine was discontinued. The 2 other patients presented with thrombocytopenic purpura and gingival bleeding over several days. Both patients developed headaches and succumbed to intracerebral hemorrhage in spite of the immediate cessation of quinidine therapy on admission and treatment with corticosteroids and platelet transfusions. In the light of this experience, we recommend that quinidine therapy of perioperative arrhythmias in patients undergoing open-heart surgery be re-evaluated, both at the time of discharge from the hospital and 1 month postoperatively, with an aim towards earlier discontinuation of quinidine whenever possible. Although a rare occurrence, quinidine-induced thrombocytopenia can evolve into a lethal cerebral hemorrhage. The response to current treatment of this rare complication is unpredictable.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
0730-2347
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-9
pubmed:dateRevised
2009-11-18
pubmed:year
1990
pubmed:articleTitle
Fatal quinidine-induced thrombocytopenia following open-heart surgery.
pubmed:affiliation
The Department of Cardiac Surgery, Kaiser Foundation Hospital, Los Angeles, California 90027, USA.
pubmed:publicationType
Journal Article