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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2004-6-30
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pubmed:abstractText |
The targeted delivery of taxoids, in the form of taxane-antibody immunoconjugates, requires the preparation of taxoids containing moieties suitable for their conjugation to monoclonal antibodies. A series of taxoids incorporating a disulfide-containing linker at various positions of the taxoid framework have been prepared to investigate the most suitable position for conjugation. A second series of taxoids modified at the C-2 position aimed at increasing the potency of these taxanes has also been prepared.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4079-82
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15225730-Antibodies, Monoclonal,
pubmed-meshheading:15225730-Antineoplastic Agents,
pubmed-meshheading:15225730-Cell Line, Tumor,
pubmed-meshheading:15225730-Cell Survival,
pubmed-meshheading:15225730-Drug Delivery Systems,
pubmed-meshheading:15225730-Drug Design,
pubmed-meshheading:15225730-Drug Screening Assays, Antitumor,
pubmed-meshheading:15225730-Humans,
pubmed-meshheading:15225730-Models, Molecular,
pubmed-meshheading:15225730-Molecular Structure,
pubmed-meshheading:15225730-Paclitaxel,
pubmed-meshheading:15225730-Structure-Activity Relationship,
pubmed-meshheading:15225730-Taxoids
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pubmed:year |
2004
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pubmed:articleTitle |
Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies.
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pubmed:affiliation |
ImmunoGen, Inc., 128 Sidney Street, Cambridge, MA 02139, USA. michael.miller@immunogen.com
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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