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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2004-6-30
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pubmed:abstractText |
Inducible cyclooxygenase-2 (COX-2) has been suggested to play a role in the processes of inflammation and carcinogenesis. Recent studies have shown the chemoprotective effects of kahweol and cafestol, which are coffee-specific diterpenes. This study investigated the effects of kahweol and cafestol on the expression of COX-2 in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Kahweol and cafestol significantly suppressed the LPS-induced production of prostaglandin E(2), COX-2 protein and mRNA expression, and COX-2 promoter activity in a dose-dependent manner. Furthermore, kahweol blocked the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity. These results will provide new insights into the anti-inflammatory and anti-carcinogenic properties of kahweol and cafestol.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Coffee,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/cafestol,
http://linkedlifedata.com/resource/pubmed/chemical/kahweol
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
569
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15225655-Animals,
pubmed-meshheading:15225655-Cell Line,
pubmed-meshheading:15225655-Coffee,
pubmed-meshheading:15225655-Cyclooxygenase 2,
pubmed-meshheading:15225655-Diterpenes,
pubmed-meshheading:15225655-I-kappa B Proteins,
pubmed-meshheading:15225655-Isoenzymes,
pubmed-meshheading:15225655-Lipopolysaccharides,
pubmed-meshheading:15225655-Macrophages,
pubmed-meshheading:15225655-Mice,
pubmed-meshheading:15225655-NF-kappa B,
pubmed-meshheading:15225655-Promoter Regions, Genetic,
pubmed-meshheading:15225655-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:15225655-RNA, Messenger,
pubmed-meshheading:15225655-Transcription, Genetic
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pubmed:year |
2004
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pubmed:articleTitle |
Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages.
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pubmed:affiliation |
Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University, Kwangju 501-759, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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