| pubmed-article:15225644 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15225644 | lifeskim:mentions | umls-concept:C0085262 | lld:lifeskim |
| pubmed-article:15225644 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:15225644 | lifeskim:mentions | umls-concept:C1333652 | lld:lifeskim |
| pubmed-article:15225644 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15225644 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15225644 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:15225644 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:15225644 | pubmed:dateCreated | 2004-6-30 | lld:pubmed |
| pubmed-article:15225644 | pubmed:abstractText | We studied the regulation of glucose-6-phosphate dehydrogenase (G6PD) gene expression by chronic hypoxia. G6PD mRNA level and activity were increased in PC12 cells by hypoxia in a dose- and time-dependent manner. Cobalt chloride and dimethyloxalylglycine, which can mimic hypoxia, also activated G6PD gene expression. Interestingly, hypoxia-induced G6PD expression followed a time course much slower than that of phosphoglycerate kinase 1 (PGK1), a hypoxia-inducible factor (HIF)-dependent glycolytic enzyme. Hypoxic-G6PD induction was almost negligible in non-excitable Buffalo rat liver cells, although in these cells PGK1 was strongly upregulated by low PO(2). Furthermore, G6PD but not PGK1 induction was blocked by the antioxidants glutathione and N-acetylcysteine. These results suggest the dependence of G6PD gene expression on HIF and intracellular redox status and the differential hypoxic regulation of glucose-metabolizing enzymes. | lld:pubmed |
| pubmed-article:15225644 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15225644 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15225644 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15225644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15225644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15225644 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15225644 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15225644 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:15225644 | pubmed:author | pubmed-author:GaoLinL | lld:pubmed |
| pubmed-article:15225644 | pubmed:author | pubmed-author:López-BarneoJ... | lld:pubmed |
| pubmed-article:15225644 | pubmed:author | pubmed-author:EchevarríaMir... | lld:pubmed |
| pubmed-article:15225644 | pubmed:author | pubmed-author:MejíasRebecaR | lld:pubmed |
| pubmed-article:15225644 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15225644 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:15225644 | pubmed:volume | 569 | lld:pubmed |
| pubmed-article:15225644 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15225644 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15225644 | pubmed:pagination | 256-60 | lld:pubmed |
| pubmed-article:15225644 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15225644 | pubmed:meshHeading | pubmed-meshheading:15225644... | lld:pubmed |
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| pubmed-article:15225644 | pubmed:meshHeading | pubmed-meshheading:15225644... | lld:pubmed |
| pubmed-article:15225644 | pubmed:meshHeading | pubmed-meshheading:15225644... | lld:pubmed |
| pubmed-article:15225644 | pubmed:meshHeading | pubmed-meshheading:15225644... | lld:pubmed |
| pubmed-article:15225644 | pubmed:meshHeading | pubmed-meshheading:15225644... | lld:pubmed |
| pubmed-article:15225644 | pubmed:meshHeading | pubmed-meshheading:15225644... | lld:pubmed |
| pubmed-article:15225644 | pubmed:meshHeading | pubmed-meshheading:15225644... | lld:pubmed |
| pubmed-article:15225644 | pubmed:meshHeading | pubmed-meshheading:15225644... | lld:pubmed |
| pubmed-article:15225644 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15225644 | pubmed:articleTitle | Induction of the glucose-6-phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells. | lld:pubmed |
| pubmed-article:15225644 | pubmed:affiliation | Laboratorio de Investigaciones Biomédicas, Departamento de Fisiología and Hospital Universitario Virgen del Rocío, Universidad de Sevilla, E-41013 Seville, Spain. | lld:pubmed |
| pubmed-article:15225644 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15225644 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:24377 | entrezgene:pubmed | pubmed-article:15225644 | lld:entrezgene |
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