| pubmed-article:15223963 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15223963 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:15223963 | lifeskim:mentions | umls-concept:C1332556 | lld:lifeskim |
| pubmed-article:15223963 | lifeskim:mentions | umls-concept:C0007140 | lld:lifeskim |
| pubmed-article:15223963 | lifeskim:mentions | umls-concept:C0521449 | lld:lifeskim |
| pubmed-article:15223963 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:15223963 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:15223963 | lifeskim:mentions | umls-concept:C0596611 | lld:lifeskim |
| pubmed-article:15223963 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:15223963 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15223963 | pubmed:dateCreated | 2004-6-29 | lld:pubmed |
| pubmed-article:15223963 | pubmed:abstractText | It is now known that gene mutation of beta-catenin with subsequent nuclear/cytoplasmic (N/C) overaccumulation of the protein plays an important role in tumorigenesis of various organs. We recently demonstrated that low-grade adenocarcinoma of the fetal lung type (L-FLAC)/well-differentiated fetal adenocarcinoma (WDFA), the epithelial prototype of classic pulmonary blastoma (CPB), shows N/C localization of beta-catenin with genetic mutation. This prompted us to further investigate the state of beta-catenin abnormality in CPB and related neoplasms. We studied 9 lung tumors previously diagnosed as biphasic pulmonary blastoma (PB). Histologically, 4 cases (median age 34 years) were CPB with l-FLAC/WDFA as the epithelial component, whereas 5 cases (median age 65 years) were a variant of carcinosarcoma with high-grade FLAC/clear cell adenocarcinoma with fetal lung features as the epithelial component, which we term the blastomatoid variant of carcinosarcoma (BCS). Immunohistochemically, all 4 CPBs showed aberrant N/C localization of beta-catenin both in the epithelial and mesenchymal components, with especially high staining intensity in the budding glands and morules. In contrast, all 5 BCSs showed preserved or diminished membranous expression and no significant N/C expression of beta-catenin in the epithelial component, and absent or focal N/C expression of beta-catenin in the mesenchymal component. Mutational analysis of exon 3 of the beta-catenin gene revealed that 3 CPBs harbored missense mutations (S29F, S37F, and S37F), whereas none of the 5 BCSs had this mutation. This study suggests that beta-catenin gene mutations may play a role in the tumorigenesis of CPB. Although CPB and BCS have often been grouped together as biphasic PB, they are different entities based on immunohistochemical and molecular analysis of beta-catenin. Immunostaining for beta-catenin is useful for the discrimination. | lld:pubmed |
| pubmed-article:15223963 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15223963 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15223963 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15223963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15223963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15223963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15223963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15223963 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15223963 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15223963 | pubmed:issn | 0147-5185 | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:TakemuraTamik... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:HaraKazuoK | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:TakagiMasayuk... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:MiyagiYoheiY | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:KossMichael... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:KitamuraHitos... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:NakataniYukio... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:InayamaYoshia... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:NozawaAkinori... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:SakamotoKazuh... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:OkaTeruakiT | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:MarkEugene... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:YamadaTetsuya... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:OgawaNobuoN | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:KashimaKenjiK | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:YokoyamaShige... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:ReslMilanM | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:YokoiToyoharu... | lld:pubmed |
| pubmed-article:15223963 | pubmed:author | pubmed-author:ChoSang-HoSH | lld:pubmed |
| pubmed-article:15223963 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15223963 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:15223963 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15223963 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15223963 | pubmed:pagination | 921-7 | lld:pubmed |
| pubmed-article:15223963 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:15223963 | pubmed:meshHeading | pubmed-meshheading:15223963... | lld:pubmed |
| pubmed-article:15223963 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15223963 | pubmed:articleTitle | Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma. | lld:pubmed |
| pubmed-article:15223963 | pubmed:affiliation | Department of Pathology, Yokohama City University Medical Center, Yokohama, Japan. nakatani@faculty.chiba-u.jp | lld:pubmed |
| pubmed-article:15223963 | pubmed:publicationType | Journal Article | lld:pubmed |
