Source:http://linkedlifedata.com/resource/pubmed/id/15223963
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2004-6-29
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| pubmed:abstractText |
It is now known that gene mutation of beta-catenin with subsequent nuclear/cytoplasmic (N/C) overaccumulation of the protein plays an important role in tumorigenesis of various organs. We recently demonstrated that low-grade adenocarcinoma of the fetal lung type (L-FLAC)/well-differentiated fetal adenocarcinoma (WDFA), the epithelial prototype of classic pulmonary blastoma (CPB), shows N/C localization of beta-catenin with genetic mutation. This prompted us to further investigate the state of beta-catenin abnormality in CPB and related neoplasms. We studied 9 lung tumors previously diagnosed as biphasic pulmonary blastoma (PB). Histologically, 4 cases (median age 34 years) were CPB with l-FLAC/WDFA as the epithelial component, whereas 5 cases (median age 65 years) were a variant of carcinosarcoma with high-grade FLAC/clear cell adenocarcinoma with fetal lung features as the epithelial component, which we term the blastomatoid variant of carcinosarcoma (BCS). Immunohistochemically, all 4 CPBs showed aberrant N/C localization of beta-catenin both in the epithelial and mesenchymal components, with especially high staining intensity in the budding glands and morules. In contrast, all 5 BCSs showed preserved or diminished membranous expression and no significant N/C expression of beta-catenin in the epithelial component, and absent or focal N/C expression of beta-catenin in the mesenchymal component. Mutational analysis of exon 3 of the beta-catenin gene revealed that 3 CPBs harbored missense mutations (S29F, S37F, and S37F), whereas none of the 5 BCSs had this mutation. This study suggests that beta-catenin gene mutations may play a role in the tumorigenesis of CPB. Although CPB and BCS have often been grouped together as biphasic PB, they are different entities based on immunohistochemical and molecular analysis of beta-catenin. Immunostaining for beta-catenin is useful for the discrimination.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0147-5185
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| pubmed:author |
pubmed-author:ChoSang-HoSH,
pubmed-author:HaraKazuoK,
pubmed-author:InayamaYoshiakiY,
pubmed-author:KashimaKenjiK,
pubmed-author:KitamuraHitoshiH,
pubmed-author:KossMichael NMN,
pubmed-author:MarkEugene JEJ,
pubmed-author:MiyagiYoheiY,
pubmed-author:NakataniYukioY,
pubmed-author:NozawaAkinoriA,
pubmed-author:OgawaNobuoN,
pubmed-author:OkaTeruakiT,
pubmed-author:ReslMilanM,
pubmed-author:SakamotoKazuhiroK,
pubmed-author:TakagiMasayukiM,
pubmed-author:TakemuraTamikoT,
pubmed-author:YamadaTetsuyaT,
pubmed-author:YokoiToyoharuT,
pubmed-author:YokoyamaShigeoS
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| pubmed:issnType |
Print
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| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
921-7
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| pubmed:dateRevised |
2005-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15223963-Adult,
pubmed-meshheading:15223963-Aged,
pubmed-meshheading:15223963-Carcinosarcoma,
pubmed-meshheading:15223963-Cell Nucleus,
pubmed-meshheading:15223963-Cytoplasm,
pubmed-meshheading:15223963-Cytoskeletal Proteins,
pubmed-meshheading:15223963-Diagnosis, Differential,
pubmed-meshheading:15223963-Female,
pubmed-meshheading:15223963-Humans,
pubmed-meshheading:15223963-Immunohistochemistry,
pubmed-meshheading:15223963-Lung Neoplasms,
pubmed-meshheading:15223963-Male,
pubmed-meshheading:15223963-Middle Aged,
pubmed-meshheading:15223963-Mutation,
pubmed-meshheading:15223963-Pulmonary Blastoma,
pubmed-meshheading:15223963-Trans-Activators,
pubmed-meshheading:15223963-beta Catenin
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| pubmed:year |
2004
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| pubmed:articleTitle |
Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma.
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| pubmed:affiliation |
Department of Pathology, Yokohama City University Medical Center, Yokohama, Japan. nakatani@faculty.chiba-u.jp
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| pubmed:publicationType |
Journal Article
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